Protein Alignment SLC12A2 and kcc

DIOPT Version :10

• Sequence 1: NP_001037.1
• Gene: SLC12A2 / 6558
• HGNCID: 10911
• Length: 1212
• Species: Homo sapiens
• Sequence 2: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Alignment Length: 1169
• Identity: 308/1169 - (26%)
• Similarity: 487/1169 - (41%)
• Gaps: 312/1169 - (26%)

Human   229 HTAAQLGEKLLRPSLAELHDELEKEP----FEDGFANGEESTP-TRDAVVTYTAESKGVVKFGWI 288
            |.|.:..:..:.|:|....|:||..|    |....||.|.:.| ..|......|.|   .:.|.:
  Fly    36 HRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPS---ARMGTL 97

Human   289 KGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAY 353
            .||.:.|:.||:||:|||||:|:||.||.....|:::....||.:|.:|.|||||||.|..||:|
  Fly    98 IGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSY 162

Human   354 YLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-------EINDIRI 411
            ::||||||||||||:|::|.....:|.|||:||..|.|:..:...:.:..|       ..|:.|:
  Fly   163 FMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRV 227

Human   412 IGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTF---------------------I 455
            .|.:.::.:..|...|:::..|...|.|..::|:|....:|.|                     |
  Fly   228 YGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDI 292

Human   456 PLES---------------------------KKPKGFFGYKSEIFNENFGPDFREEETFFS---- 489
            |||:                           .|.||..|..|.:|.:|..|.|.|:..|.|
  Fly   293 PLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKS 357

Human   490 -------------------------VFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILIT 529
                                     :..||||:.|||:||:|.||||||.|.:||.||:.|||.|
  Fly   358 AIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTT 422

Human   530 TLVYVG----IAVSVGSCVVRDATG-NVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNN 589
            :.||:.    .|.:|.:.::||..| ::...:|.                       .:....|.
  Fly   423 STVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVV-----------------------ANIAWPNQ 464

Human   590 FQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRG 654
            :           :|..|.|.:||.:.|.||..||::.||:.:|.|.|....|||. .|..||.|.
  Fly   465 W-----------VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRA 517

Human   655 YILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
            .:||.:|....||:..::::||::|.|||..|..:|.:....:|.::|.|||.||:|:..:||:|
  Fly   518 LLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIG 582

Human   720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHV 784
            ..||..||.:.:|:.||:...:.:.:|.|:.|:..:..||...:.:....|....:||.....|.
  Fly   583 LTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHT 647

Human   785 KNFRPQCLVMTGAPNSRPALLHLVHDFTKNV----GLMICGHVHMGPRRQAMKEMSIDQAKYQRW 845
            ||:|||.||::...::.......:..|...:    ||.||..|..|...:...:....:|..:::
  Fly   648 KNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKY 712

Human   846 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDA 910
            :...|:|.|...:.|..:.||...::|..|||.|||||:::|:...|.|........:|......
  Fly   713 MTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTV 777

Human   911 FDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITH 975
            ......::|.:                               .:.:..:|:             |
  Fly   778 AACHMALMVPK-------------------------------GINFYPESN-------------H 798

Human   976 KVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIP 1040
            |:                                          |.| ||:||:..||||.:|:|
  Fly   799 KI------------------------------------------GGN-IDIWWIVHDGGLLMLLP 820

Human  1041 YLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRIDFSDIMVL----GDINTKP--- 1096
            :||...:.|::||:|:|...:|  |.|.. ::.:.|.|...||: :|:.|:    .||:...
  Fly   821 FLLKQHRTWRNCKLRIFTVAQIEDNSIQM-KKDLKTFLYHLRIE-ADVEVVEMNNSDISAYTYER 883

Human  1097 -----------------KKEN------IIAFEE-------------------------------- 1106
                             ||||      |:.::|
  Fly   884 TLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADP 948

Human  1107 IIEPYRLHE---DDKEQDI-------AD----KMKEDEPWRITDNEL-------ELYKTKTYRQI 1150
            .||..:.|:   |:|...|       ||    ...:||.....|.:.       |....:.:..|
  Fly   949 TIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAI 1013

Human  1151 RLNELLKEHSSTANIIVMSLPVARK--GAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1212
            :|||::.|.|..|.:::|:||...:  .|.....||.:||.|::.|..:|:|||..:.|:|.||
  Fly  1014 KLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A2	NP_001037.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81
		RFXV motif 1. /evidence=ECO:0000269|PubMed:16669787	80..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..138
		RFXV motif 2. /evidence=ECO:0000269|PubMed:16669787	138..141
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..193
		2a30	216..1212	CDD:273347	306/1167 (26%)
		Scissor helix. /evidence=ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP	761..778		2/16 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989		2/26 (8%)
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	303/1154 (26%)