DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC12A2 and CG12773

DIOPT Version :10

Sequence 1:NP_001037.1 Gene:SLC12A2 / 6558 HGNCID:10911 Length:1212 Species:Homo sapiens
Sequence 2:NP_569905.1 Gene:CG12773 / 31082 FlyBaseID:FBgn0024365 Length:712 Species:Drosophila melanogaster


Alignment Length:604 Identity:166/604 - (27%)
Similarity:264/604 - (43%) Gaps:172/604 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   283 VKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFV 347
            |.||...||...|::|::||::|:|..|||.||||..:||:|....|:..::.||...|.....|
  Fly    90 VLFGTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILNAVLIIFCTVVIALVSVLSAIGICERCRV 154

Human   348 RGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELL-KEHSILMIDEINDIRI 411
            ..||.|:||:.:||..||||:||::.|..||..|:.|:||.|::..|: .|.|...|...     
  Fly   155 ESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNVMGFGESMAGLVGLEGSKWAIRGF----- 214

Human   412 IGAITVVILLG-ISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNE 475
              |...|:||| |:|||::|..|.|.:||:|||::..||::|:|   .|:...||.|:.|..|.|
  Fly   215 --ATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF---TSEASGGFNGWASGNFVE 274

Human   476 NFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSV 540
            |..|.:.:..::|.||.:|||..||:|:|.|:||||..|.:.||.|||.|...:|.:|:...:.:
  Fly   275 NLWPKYDDGYSWFRVFGVFFPTVTGVLSGINMSGDLRAPSTDIPNGTLAAFGTSTFLYLVFVLFL 339

Human   541 GSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISA 605
            |                        |.|:.:|             |..::.:...||....|:.|
  Fly   340 G------------------------ATCQRSF-------------LYTDYMISVKVSAVHFLLLA 367

Human   606 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAE 670
            ||:.:::||.|.::...|::.|::.|:::.|...:..||.|.|..||....:..|:.:.||::.:
  Fly   368 GIYVSSMSSCLGAMYGTPRVLQSIAKESVIPGIDILGKGRGPNKVPLYAMAIVALVTVTFIIVGD 432

Human   671 LNVIAPIISNFFLASYALINFSVF----------------------------------------- 694
            :|.:|||::..||.:||.|:::.|                                         
  Fly   433 INFLAPIVTMPFLLTYACIDYAYFALAQTFDIQEQREERFRIQASSPSYETRRYGSVSDTGNDLD 497

Human   695 --------HASL----------------------------------------------------- 698
                    |.:|                                                     
  Fly   498 LLFPDRVRHKNLQSPQNSPLHQTVPLEFDNEGPSTSNQAQSSERRTGHEADTTLAVEQAVAQAGV 562

Human   699 -------------------AKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLG 744
                               :|:..|...  |.|.|.|||||....:||.::||:.||..:::|..
  Fly   563 EQDQGDEAEPIAPIRPPIHSKTKNWYSG--YCNRWASLLGAFTKLLVMLLVNWYYALTCFLVVFV 625

Human   745 LYIYVTYKKPDVNWGSSTQ 763
            ::.||....|.|..|.:.:
  Fly   626 VWFYVGTANPAVKPGLTAE 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC12A2NP_001037.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..81
RFXV motif 1. /evidence=ECO:0000269|PubMed:16669787 80..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..138
RFXV motif 2. /evidence=ECO:0000269|PubMed:16669787 138..141
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..193
2a30 216..1212 CDD:273347 166/604 (27%)
Scissor helix. /evidence=ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP 761..778 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..989
CG12773NP_569905.1 AA_permease_2 88..>456 CDD:459263 141/412 (34%)
Blue background indicates that the domain is not in the aligned region.

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