Protein Alignment SLC12A2 and vhc1

DIOPT Version :10

• Sequence 1: NP_001037.1
• Gene: SLC12A2 / 6558
• HGNCID: 10911
• Length: 1212
• Species: Homo sapiens
• Sequence 2: NP_001342720.1
• Gene: vhc1 / 2540830
• PomBaseID: SPBC18H10.16
• Length: 1050
• Species: Schizosaccharomyces pombe
• Alignment Length: 1137
• Identity: 264/1137 - (23%)
• Similarity: 459/1137 - (40%)
• Gaps: 289/1137 - (25%)

Human   245 ELHDELE------KEPFEDGFANGEESTPTRDAVVTYTAESK---GVVKFGWIKGVLVRCMLNIW 300
            |..:.||      :||.:...:|.....|.....||: ||::   ..||.|..:|..:...||:.
pombe    29 ETQENLESSTPLLQEPQQSYRSNSFNELPPLSRSVTF-AENEQPNEAVKLGTFEGCFIPTTLNVL 92

Human   301 GVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG 365
            .::|::|..||:|:||:..::|::.::..|...|.||.|||.|||.||||||||.:|||:|||.|
pombe    93 SILLYLRFPWIIGEAGVLKTLLMLFISYAVGIFTSLSISAICTNGMVRGGGAYYAVSRSIGPELG 157

Human   366 GAIGLIFAFANAVAVAMYVVGFAETVVELL-KEHSIL--MIDE------INDIRIIGAITVVILL 421
            |:|||||.....:...|.:.||.|.::.:. ||...:  .:.|      :....::....::..|
pombe   158 GSIGLIFYVGQILNTGMNISGFVEPIISIFGKESGTISQFLPEGYWWVFLYTTCVLAMCCILCCL 222

Human   422 GISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPK---GFFGYKSEIFNENFGPDFRE 483
            |.::.     |||...|.|:::|:.....|.:......|.|.   .|.|.|.....:|....:.|
pombe   223 GSAIF-----AKASNALFVVIILSTISIPISSIFVHPFKDPSLLVHFTGLKWSTLMKNLASAYTE 282

Human   484 E------ETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGS 542
            .      |:|.|.|.:||||..|:||||::||||..|..:|||||:.:...|.|:|:.:.:.||:
pombe   283 NEKGTGYESFKSTFGVFFPATAGLLAGASMSGDLKAPSRSIPKGTISSQATTFLLYLLVILCVGA 347

Human   543 CVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGI 607
            .|.|.                                     ||:.:..||..:|.....|.:||
pombe   348 SVTRT-------------------------------------GLLLDMDVMEHISLHPLFIISGI 375

Human   608 FSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELN 672
            .|:...|:...:..|.|:.||:.:|::.|....||||...::.|.....:|:||. ...|..::|
pombe   376 LSSGAFSSFMGIFGAAKLLQAIARDDLIPGMFFFAKGSSYDDIPYVAIGVTYLIT-QISLFWDIN 439

Human   673 VIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALL 737
            :::.:|:..||.::..||.|.|...::.:|.:||.|:|:|...:|:|.||...|||.::...|.:
pombe   440 MLSSMITMTFLLTFGFINLSCFLLRISSTPNFRPTFRYFNRRTTLVGTILSFGVMFYVDRLNAFI 504

Human   738 TYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRP 802
            :::|...|.:.:.:..|..|||..:|.:.|....::.::.:...:::|.:|||.|::...||...
pombe   505 SFLIAGILVVVIYFTCPPKNWGDVSQGIIYHQLRKYLLQTNKARENIKFWRPQILLLINNPNRSE 569

Human   803 ALLHLVHDFTKNVGLMICGHVHMGPRRQA-MKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREG 866
            .::...:...|. .|.|.|||.:....|| |.::...|..:.::::...:|||.....|.|...|
pombe   570 NVIRFCNSLKKG-SLYILGHVIVSDDFQASMDDLRKQQRLWHQFVLDRGIKAFVELTIAPDEVWG 633

Human   867 AQYLMQAAGLGRMKPNTLVLGF-----------------------------KKDWLQADMRDVDM 902
            .:.|:.:||||.::||..||.|                             ||::::.|:
pombe   634 IRGLISSAGLGGIRPNIAVLTFINTNYRRHRIYSGSSFSLENTSEESESDSKKEFVEHDI----- 693

Human   903 YINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKP 967
                                   |.:..:|..|::|      .|:.||:|:..:.:   |:..|.
pombe   694 -----------------------LPVKWVQILEDML------VGSVDVMVTNGFDR---LNWPKR 726

Human   968 LSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDD 1032
            ..||......                   ||..::....::.|::..|...           |:.
pombe   727 KGEKQYIDMF-------------------PIHRISGVGSEVNESTPTFATN-----------FET 761

Human  1033 GGLTLLIPYLLTTKKKWKD-CKIRVFIGGKI-NRIDHDRRAMATLLSKFRIDFSDIMVL------ 1089
            ..:...:.::|.|...||. |::|:....:. |.|:.:|.:|..:|..|||. :|::||
pombe   762 YTMVFQLSWILHTASDWKQGCRLRLITLVEFENEIEAERESMHQMLETFRIK-ADVVVLCLAAMN 825

Human  1090 ----------------------------------------------------------------- 1089
                                                                             
pombe   826 LDAYRYIVKNEHVRPSKSSELENLLKDDSWWQEEKKRRGNTVDSLGPIRFPRRMSGYNFRSASFD 890

Human  1090 ------------------------------GDINTKPKKENIIAF-----EEIIEPYRLHEDDKE 1119
                                          |:.:..||:||...:     |..:.|..:.||...
pombe   891 KSAPPLSVPLSFRLGPHMHSVKSFETESSFGNRSLSPKQENRRTYSDSTIESSLMPNVVREDSSS 955

Human  1120 QDIADKMKEDEPW---RITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPV----ARKGA 1177
            ..:|.|.|....:   ::|.|:|    :...:.|.:||::.:|:...:::...||.    ..|..
pombe   956 DRLAPKKKIGRDYSKEKLTFNDL----SSRSQYIIMNEIVLKHTKNTSVLFTVLPAPLADTHKSF 1016

Human  1178 VSSALYMAWLEALSKDLPPILLVRGNHQSVLT 1209
            ..|..|:..|....:.|||..|:.....::.|
pombe  1017 RKSEEYVDDLLIFMEGLPPCALIHSKSLTITT 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A2	NP_001037.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81
		RFXV motif 1. /evidence=ECO:0000269|PubMed:16669787	80..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..138
		RFXV motif 2. /evidence=ECO:0000269|PubMed:16669787	138..141
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..193
		2a30	216..1212	CDD:273347	264/1137 (23%)
		Scissor helix. /evidence=ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP	761..778		2/16 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989		4/26 (15%)
vhc1	NP_001342720.1	AA_permease_2	57..818	CDD:459263	226/873 (26%)