Protein Alignment SLC12A1 and VHC1

DIOPT Version :10

• Sequence 1: NP_000329.2
• Gene: SLC12A1 / 6557
• HGNCID: 10910
• Length: 1099
• Species: Homo sapiens
• Sequence 2: NP_009794.3
• Gene: VHC1 / 852537
• SGDID: S000000439
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 1223
• Identity: 281/1223 - (22%)
• Similarity: 473/1223 - (38%)
• Gaps: 363/1223 - (29%)

Human   124 PKVNRPSLLEIHEQLAKNVAVTPSSADRVA----NGDGIPGDEQAENKED-DQAGVVKFGWVKGV 183
            |..:|||    ....:.|.:.:..||.|::    |....|..::..:|.| |.....|.|...||
Yeast     9 PGTHRPS----SAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPNKDKLGTYDGV 69

Human   184 LVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLI 248
            .|...||:..:::|:|..:|:|:.||...:.::|||..:..:|.||.|||:|||.||||||||:|
Yeast    70 FVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNGTVRGGGAYYMI 134

Human   249 SRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSI------ 307
            ||||||||||||||:|.........|..||..|.:  |.....|...:|.   ..:|.:
Yeast   135 SRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPL--LYNLGYSAQGEPP---AALGELLPRGHW 194

Human   308 ------TVVILLGISVA--GMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQAS 364
                  ||::.|..|||  |.:..::|..||.::|..:|.:..:..:|.|...:....:......
Yeast   195 HEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSALIRSPFTEGGISYTGPSWQ 259

Human   365 IFAENFGPRFTKG---------EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIF 420
            .|.:|..|..|||         |.|..:|.:||||..||.|||.:|.:|..|..:||:||:..:.
Yeast   260 TFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLL 324

Human   421 ITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQV 485
            .|.:.|..|...:|..:.|.:                                     |.:..|:
Yeast   325 FTFICYAVVVFSMGCSIPRRS-------------------------------------LYDEVQI 352

Human   486 MSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYIL 550
            :..:|....:|..|..:.:|.|.:..::.|..|.:|:.||||...|:.||      :.||...|.
Yeast   353 IQTISSVQWVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFA------HSPLYSLIF 411

Human   551 TFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVL 615
            |:::.. ..|.:::|.||..|:..||.::.::|.:||....:.:|.:||::..:|.:.:..||:|
Yeast   412 TWILTQ-LCLFSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALL 475

Human   616 CCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNF 680
            ....|.:::..:|.:.::....|::::....|..:||..:|:|.|.......|.|.  :|::|.:
Yeast   476 SVVAMLIVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLR--QDNIKYW 538

Human   681 RPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVG---PRKLCVKEMNSGMAKKQAWL-IK 741
            |||.::....|.|...|:...: ..|..||.|...|.|.   |     |::|....:::||: |:
Yeast   539 RPQILLFVDNPRTSWNLIRFCN-HLKKGGLYILGHVAVTADFP-----KQLNELKTQQKAWMKIR 597

Human   742 N--KIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGY--KKNWRK-APLTEIENYVGIIH 801
            :  .||||...........|:|::...||||.||||..|:|:  .:::|| .|.:..:|.:
Yeast   598 DMAAIKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNL---- 658

Human   802 DAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGK 866
                                              |:::.::||:..:.|.:.            |
Yeast   659 ----------------------------------QKQVEIKATVPRSTCSDV------------K 677

Human   867 LNITKTTP--KKDGSINTSQSMHVGE---FNQKLVEASTQFKKKQ---------EKGTIDVWWL- 916
            :|:...|.  |.:..:|..|.:.:.|   ..|..:..:..||..:         .|.|||::.:
Yeast   678 INVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKNLEIPNKRDSCFPKKTIDLYPIQ 742

Human   917 ------------------FDDGGLTLLIPYILTLRKKWK---DCKLRIYVGGKINRIEEEKIVMA 960
                              ||...|.|.:..||....:||   ..::.::|..:.:|..|.: .|.
Yeast   743 MCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEWKRTHSLRVILFVEQEYHRTNETQ-RMK 806

Human   961 SLLSKFRIKFADIHII-------------GD------INIR-PNKESWKVFEE------------ 993
            .||...||. |::.::             ||      :|.: .:.|.||...|
Yeast   807 KLLQVLRID-AEVLVVSLDQFRVYNTIVKGDPIVFDYVNSKLADNEWWKDLVEARDTLKPKRRFS 870

Human   994 MIEPY--------------------------------RLHESC---------------------- 1004
            .|||.                                |:...|
Yeast   871 TIEPQTIAKQFTQSRKYTSGVQKLGVSFTMNTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSAST 935

Human  1005 -----KDLTT------------------------------------------------------- 1009
                 |||||
Yeast   936 NISVGKDLTTKSKTGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAE 1000

Human  1010 ---------------AEKLKRE-----TPWKITDAELEAVKEKSY-------RQVRLNELLQEHS 1047
                           ..|||:.     :|....|:.:.|::...:       :.:.||:::.:.|
Yeast  1001 PDLSNGNGTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMS 1065

Human  1048 RAANLIVLSLPVARKGSISD----LLYMAWLEILTKNLPPVLLVRGNHKNVLT 1096
            ::::||..:|||...|:..|    |.|:..|:|..:.|||.:|:......|.|
Yeast  1066 KSSDLIFSTLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTT 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A1	NP_000329.2	RFXV motif. /evidence=ECO:0000269|PubMed:21321328	20..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..53
		2a30	104..1099	CDD:273347	281/1223 (23%)
VHC1	NP_009794.3	AA_permease_2	45..824	CDD:459263	228/887 (26%)