Protein Alignment SLC12A1 and Ncc69

DIOPT Version :10

• Sequence 1: NP_000329.2
• Gene: SLC12A1 / 6557
• HGNCID: 10910
• Length: 1099
• Species: Homo sapiens
• Sequence 2: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Alignment Length: 1232
• Identity: 531/1232 - (43%)
• Similarity: 731/1232 - (59%)
• Gaps: 193/1232 - (15%)

Human    19 NRFQVSVINENHESSAAADD---------------NTDPPH------------------YEETSF 50
            |||||:.:|.|...|..||.               ..|.||                  ::.|..
  Fly    18 NRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQM 82

Human    51 GDEAQKR-----LRISFR--------------------PGNQECYDNFLQSGETAKTDASFHAYD 90
            .::.|.|     ::.|||                    |.|:|       |.|:..:.......|
  Fly    83 LNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEE-------SDESNDSQEERELLD 140

Human    91 SHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANG 155
            :..:|.|.::|.|.|.:|:|:::.|||..||..  ..||:|.|:|.  |..|.....|..|
  Fly   141 NEYDTKYGKSFRHFTREALPRLDNYRNMMSIQA--AYRPTLDELHN--ATLVGKNTHSLTR---- 197

Human   156 DGIPGDEQAENKEDDQA---GVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIIL 217
                      |::.:..   ||:||||:|||||||:|||||||||:||||:||:||:..|.::||
  Fly   198 ----------NQDPESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLIL 252

Human   218 LSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAET 282
            .:|.||:||.||.|||:|||.::|||.||:|||||||||||||||||:.|||||.|||||||.|:
  Fly   253 TTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCES 317

Human   283 VVDLLKESDSMMVD-PTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTV 346
            ::.::......::| ...|:||||.||:::||.|.|.|||||||||:.||:|||:||.:|.||:.
  Fly   318 MLAMMTTFGWEIIDGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSF 382

Human   347 I-PSNNEKKSRGFFNYQASIFAENFGPRFTKGEG-----FFSVFAIFFPAATGILAGANISGDLE 405
            | |.::.:.::||..|.|::|..|....:...:|     |||||||||||||||||||||||||:
  Fly   383 IGPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLK 447

Human   406 DPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRC 470
            |||.:||:||:|||.|||..||.:.:..||.|.||||||::|.:      ||:.|      |..|
  Fly   448 DPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVV------NGTFA------FLDC 500

Human   471 RHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535
            :...|.|||.|:|||:.:||.|||||.||.::|||||||||||||||||||||||.:|..:.:||
  Fly   501 QPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFA 565

Human   536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPA 600
            |||||||||:|||:|||:||.|||||.|||.|||:|||||||:|.|||||.||||.||..||||.
  Fly   566 KGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPT 630

Human   601 YGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALD 665
            :..||||:||.||:||.||||:|:|..|:||:.....||:.|..:||||||||:|||.:|.:||.
  Fly   631 FKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALM 695

Human   666 NALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
            :..:|..||:||||:|||.:||:|.|.|||.|:|:.:..|||..|.:|..|..|...   ::..:
  Fly   696 SVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSS---QKYRT 757

Human   731 GMAKKQA-WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIE 794
            .:.::.. |..|:::|.|||.|..:.|..|.|:|:||:|:|::|||.:::|||.:|:.....|::
  Fly   758 YLQERAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELD 822

Human   795 NYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQE------------------------------ 829
            .|..::|.|.|..:.|.|:|:.||.|.||||..|:
  Fly   823 QYFNVMHKALDMYLSVAILRVPQGLDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRN 887

Human   830 ---------------------ELERLEQERL-------------------ALEAT-----IKDNE 849
                                 :|...||..|                   |..:|     |..|:
  Fly   888 GLSGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQ 952

Human   850 CEEESGGIRGLFKKAGKL---NITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTI 911
            .::.||....|..|:..|   ::.|:..|.|...:..:.....|..::::...|||.:|:....|
  Fly   953 SKDVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVI 1017

Human   912 DVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIY-VGGKINRIEEEKIVMASLLSKFRIKFADIHI 975
            |||||:||||||||:|||::.|:.|:.||||:| :..|.:.:|.|:..||||||||||.::|:.:
  Fly  1018 DVWWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTL 1082

Human   976 IGDINIRPNKESWKVFEEMIEPYRLHESCKD---LTTAEKLKRETPWKITDAELEAVKEKSYRQV 1037
            |.||..:|.:.|.:.|.|:|:.:.:.|  ||   .|::.....|....|||.:|.||::|:.|.:
  Fly  1083 IPDITKKPQETSTQFFNELIKDFVVTE--KDGENGTSSRATLNEDDALITDDDLLAVQDKTNRYL 1145

Human  1038 RLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
            ||.|.|:|.|..::|:|::||:.||..:|..|||||||.|::::||.|.||||..:||||||
  Fly  1146 RLREYLREQSTKSDLVVMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A1	NP_000329.2	RFXV motif. /evidence=ECO:0000269|PubMed:21321328	20..23		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..53		7/54 (13%)
		2a30	104..1099	CDD:273347	500/1087 (46%)
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	500/1086 (46%)