Protein Alignment SLC12A1 and vhc1

DIOPT Version :10

• Sequence 1: NP_000329.2
• Gene: SLC12A1 / 6557
• HGNCID: 10910
• Length: 1099
• Species: Homo sapiens
• Sequence 2: NP_001342720.1
• Gene: vhc1 / 2540830
• PomBaseID: SPBC18H10.16
• Length: 1050
• Species: Schizosaccharomyces pombe
• Alignment Length: 1105
• Identity: 280/1105 - (25%)
• Similarity: 452/1105 - (40%)
• Gaps: 297/1105 - (26%)

Human   164 AENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGL 228
            |||::.::|  ||.|..:|..:...||:..::|::|..||:||||:...:|::.:|..|...|.|
pombe    66 AENEQPNEA--VKLGTFEGCFIPTTLNVLSILLYLRFPWIIGEAGVLKTLLMLFISYAVGIFTSL 128

Human   229 STSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLL-KESDS 292
            |.|||.|||.||||||||.:|||:|||.||||||||.....:...|.:.||.|.::.:. |||.:
pombe   129 SISAICTNGMVRGGGAYYAVSRSIGPELGGSIGLIFYVGQILNTGMNISGFVEPIISIFGKESGT 193

Human   293 M-MVDPTN-------DIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPS 349
            : ...|..       ...::....::..||.::......|...||:|..:.|.|::.|   |.|.
pombe   194 ISQFLPEGYWWVFLYTTCVLAMCCILCCLGSAIFAKASNALFVVIILSTISIPISSIF---VHPF 255

Human   350 NNEKKSRGFFNYQASIFAENFGPRFT---KG---EGFFSVFAIFFPAATGILAGANISGDLEDPQ 408
            .:......|...:.|...:|....:|   ||   |.|.|.|.:||||..|:||||::||||:.|.
pombe   256 KDPSLLVHFTGLKWSTLMKNLASAYTENEKGTGYESFKSTFGVFFPATAGLLAGASMSGDLKAPS 320

Human   409 DAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHE 473
            .:||:||:.:...|.:.||.|.:||||.|.|.
pombe   321 RSIPKGTISSQATTFLLYLLVILCVGASVTRT--------------------------------- 352

Human   474 PCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGY 538
                ||:.:..||..:|.....|.:||.|:...|:...:..|.|:.||:.:|::...:.|||||.
pombe   353 ----GLLLDMDVMEHISLHPLFIISGILSSGAFSSFMGIFGAAKLLQAIARDDLIPGMFFFAKGS 413

Human   539 GKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGI 603
            ..::.|.....:|:||.. ..|..::|.::.:|:..||.::..||.|||....:.:|.:||.:..
pombe   414 SYDDIPYVAIGVTYLITQ-ISLFWDINMLSSMITMTFLLTFGFINLSCFLLRISSTPNFRPTFRY 477

Human   604 YNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYV--YVTCKKPDVNWGSSTQALSYVSALDN 666
            :|...:|.|.:|...|||.::...|.|:::|...|.|  |.||  |..|||..:|.:.|......
pombe   478 FNRRTTLVGTILSFGVMFYVDRLNAFISFLIAGILVVVIYFTC--PPKNWGDVSQGIIYHQLRKY 540

Human   667 ALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNS----GLCICCEVFVGPRKLCVKE 727
            .|:.....:::|.:|||.::|...|.....::...::..|.|    |..|..:.|..       .
pombe   541 LLQTNKARENIKFWRPQILLLINNPNRSENVIRFCNSLKKGSLYILGHVIVSDDFQA-------S 598

Human   728 MNSGMAKKQAW---LIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGY-KKNWRKA 788
            |:....:::.|   ::...||||.....|.....|:|.|:.::|||.::||..|:.: ..|:|:.
pombe   599 MDDLRKQQRLWHQFVLDRGIKAFVELTIAPDEVWGIRGLISSAGLGGIRPNIAVLTFINTNYRRH 663

Human   789 PL-----TEIEN----------------------YVGIIHDAFDFEIGVVIVRISQGFDISQVLQ 826
            .:     ..:||                      :|.|:.|..   :|.|.|.::.|||
pombe   664 RIYSGSSFSLENTSEESESDSKKEFVEHDILPVKWVQILEDML---VGSVDVMVTNGFD------ 719

Human   827 VQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGS---INTSQSMHV 888
                                                   :||    .||:.|.   |:......:
pombe   720 ---------------------------------------RLN----WPKRKGEKQYIDMFPIHRI 741

Human   889 GEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKD-CKLRIYVGGKI-NR 951
            .....::.|::..|....|..|           :...:.:||.....||. |:||:....:. |.
pombe   742 SGVGSEVNESTPTFATNFETYT-----------MVFQLSWILHTASDWKQGCRLRLITLVEFENE 795

Human   952 IEEEKIVMASLLSKFRIKFADI--------------HIIGDINIRPNK----------ESW---- 988
            ||.|:..|..:|..|||| ||:              :|:.:.::||:|          :||
pombe   796 IEAERESMHQMLETFRIK-ADVVVLCLAAMNLDAYRYIVKNEHVRPSKSSELENLLKDDSWWQEE 859

Human   989 ---------------------------KVFEEMIEP------YRL--H-ESCKDLTTAEKL---- 1013
                                       ..|::...|      :||  | .|.|...|....
pombe   860 KKRRGNTVDSLGPIRFPRRMSGYNFRSASFDKSAPPLSVPLSFRLGPHMHSVKSFETESSFGNRS 924

Human  1014 ---KRETPWKITDAELEA------VKEKS--------------YRQVRL--------------NE 1041
               |:|.....:|:.:|:      |:|.|              |.:.:|              ||
pombe   925 LSPKQENRRTYSDSTIESSLMPNVVREDSSSDRLAPKKKIGRDYSKEKLTFNDLSSRSQYIIMNE 989

Human  1042 LLQEHSRAANLI--VLSLPVA------RKGS--ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLT 1096
            ::.:|::..:::  ||..|:|      ||..  :.|||      |..:.|||..|:   |...||
pombe   990 IVLKHTKNTSVLFTVLPAPLADTHKSFRKSEEYVDDLL------IFMEGLPPCALI---HSKSLT 1045

Human  1097  1096
            pombe  1046  1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A1	NP_000329.2	RFXV motif. /evidence=ECO:0000269|PubMed:21321328	20..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..53
		2a30	104..1099	CDD:273347	280/1105 (25%)
vhc1	NP_001342720.1	AA_permease_2	57..818	CDD:459263	237/867 (27%)