Protein Alignment SLC12A1 and slc12a1

DIOPT Version :10

• Sequence 1: NP_000329.2
• Gene: SLC12A1 / 6557
• HGNCID: 10910
• Length: 1099
• Species: Homo sapiens
• Sequence 2: XP_002936613.2
• Gene: slc12a1 / 100490198
• XenbaseID: XB-GENE-479925
• Length: 1086
• Species: Xenopus tropicalis
• Alignment Length: 1097
• Identity: 846/1097 - (77%)
• Similarity: 963/1097 - (87%)
• Gaps: 11/1097 - (1%)

Human     3 LNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQ 67
            :|||.|.|||:.|.:.:||||:|:.|.:::.|..|  .|||.||||||.|:.    |:|:||||:
 Frog     1 MNNSPNTFLDTAPISPSRFQVNVVGEGYDNPACED--KDPPDYEETSFADDN----RMSYRPGNR 59

Human    68 ECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLL 132
            |.::|.|.:|:|.||:.|||.||:|.:.||::||||||:||||||:||||||||||.|:.||||.
 Frog    60 EIFNNVLHNGDTIKTEGSFHPYDTHGHAYYMKTFGHNTVDAVPKIDYYRNTGSISGVKICRPSLA 124

Human   133 EIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLF 197
            :|||||:|||...|.|   |.||:||||||:|..:|.::.|.|||||:|||||||||||||||||
 Frog   125 DIHEQLSKNVVEVPGS---VTNGEGIPGDEEANKEEGEKGGFVKFGWIKGVLVRCMLNIWGVMLF 186

Human   198 IRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGL 262
            ||||||||:|||||||:||.||.:|||:||:|.|||.|||.||||||||||||||||||||||||
 Frog   187 IRLSWIVGQAGIGLGVVIICLSVVVTSLTGVSMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGL 251

Human   263 IFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQ 327
            |||||||||||||||||:||||::||:::::|||..|||||||:|||::||||||||||||||||
 Frog   252 IFAFANAVAVAMYVVGFSETVVEILKDTNTIMVDEVNDIRIIGTITVILLLGISVAGMEWEAKAQ 316

Human   328 VILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAAT 392
            |:|||||||||.|||||||||:..||:::|||||||:||||||||.|..||||||||||||||||
 Frog   317 VVLLVILLIAIVNFFIGTVIPTTKEKRAQGFFNYQATIFAENFGPDFRNGEGFFSVFAIFFPAAT 381

Human   393 GILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNG 457
            ||||||||||||:|||.|||:|||.||.|||:||||||||..|.||||||||:||||.|...|||
 Frog   382 GILAGANISGDLKDPQGAIPKGTMWAILITTIAYLGVAICAAASVVRDATGNLNDTITSAFKCNG 446

Human   458 SAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQAL 522
            |||||||||||.|..:.|.||||||||||||||||||||.|||||||||||||||||||||||||
 Frog   447 SAACGLGYDFSICETQTCNYGLMNNFQVMSMVSGFGPLIIAGIFSATLSSALASLVSAPKVFQAL 511

Human   523 CKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCF 587
            |||||||.|.|||||:||||||:|||:|||:||:|||||||||.|||||||||||||||||||||
 Frog   512 CKDNIYKGLHFFAKGHGKNNEPIRGYVLTFVIALAFILIAELNVIAPIISNFFLASYALINFSCF 576

Human   588 HASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWG 652
            |||||||||||||:..||||||||||:|||.||||||||||:|||.||.|||:|||.||||||||
 Frog   577 HASYAKSPGWRPAFKYYNMWVSLFGAMLCCGVMFVINWWAALITYAIELFLYIYVTYKKPDVNWG 641

Human   653 SSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVF 717
            ||||||.:.:|||:||.|..:||||||||||||||||.||||||||||||:||||||||||||||
 Frog   642 SSTQALQFKNALDSALGLNCIEDHVKNFRPQCIVLTGVPMTRPALLDITHSFTKNSGLCICCEVF 706

Human   718 VGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYK 782
            .||||..||||||||.|||.||..||.||||||||||.||||||:|||||||||:||||||:|:|
 Frog   707 SGPRKQAVKEMNSGMIKKQTWLTNNKRKAFYAAVAADNFRDGVRTLLQASGLGRLKPNTLVMGFK 771

Human   783 KNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKD 847
            |:||:|...::.|||||:|||||||.|||||||||||||||||||:||.:||||||||||.|||:
 Frog   772 KDWRQASPVDLANYVGILHDAFDFEHGVVIVRISQGFDISQVLQVKEEFDRLEQERLALEQTIKE 836

Human   848 NECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTID 912
            ||.:|.:.|:|..|.|..||||.:.:..||  ::|...|||||:||:|||||.||||.|.||.||
 Frog   837 NEFKEGNHGLRSFFNKTAKLNINRHSSTKD--VSTPPPMHVGEYNQRLVEASEQFKKNQGKGMID 899

Human   913 VWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIG 977
            |||||||||||||||:|||||||||||||||::|||:||:|:||::|||||||||||||||:|:|
 Frog   900 VWWLFDDGGLTLLIPHILTLRKKWKDCKLRIFIGGKVNRLEDEKLMMASLLSKFRIKFADIYIVG 964

Human   978 DINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNEL 1042
            |||.:|:|||||.||||||||.|||:..|::||||::||.||||||:|||..|||||||||||||
 Frog   965 DINTKPSKESWKFFEEMIEPYCLHENSTDVSTAEKIRRENPWKITDSELEMFKEKSYRQVRLNEL 1029

Human  1043 LQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
            ||||||:|||||||||||||||:||.|||||:|||:|||||||||||||||||||||
 Frog  1030 LQEHSRSANLIVLSLPVARKGSVSDHLYMAWVEILSKNLPPVLLVRGNHKNVLTFYS 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A1	NP_000329.2	RFXV motif. /evidence=ECO:0000269|PubMed:21321328	20..23		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..53		11/21 (52%)
		2a30	104..1099	CDD:273347	793/994 (80%)
slc12a1	XP_002936613.2	2a30	96..1086	CDD:273347	793/994 (80%)