Protein Alignment SLC11A1 and Mvl

DIOPT Version :10

• Sequence 1: NP_000569.3
• Gene: SLC11A1 / 6556
• HGNCID: 10907
• Length: 550
• Species: Homo sapiens
• Sequence 2: NP_001262795.1
• Gene: Mvl / 42490
• FlyBaseID: FBgn0011672
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 544
• Identity: 306/544 - (56%)
• Similarity: 384/544 - (70%)
• Gaps: 32/544 - (5%)

Human     3 GDKGPQRLSGSSYG-----------SISSPTSPTSPGPQQAPPRETYLS-EKIPIPD---TKPGT 52
            |..||...||:|.|           .|.:.|:...|..:||     |.| ||:.|||   |..|
  Fly    13 GGDGPGGSSGASGGGSQRSNQLHHQQILNETTYLKPAAKQA-----YFSDEKVLIPDDDSTNVG- 71

Human    53 FSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVT 117
            ||.||||||||||||||||:|||||||||:|:||.|.:|:|||||||||||||.|||||||||||
  Fly    72 FSFRKLWAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVT 136

Human   118 GKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTF 182
            |..|.|:|:..|.::||.:||:.||:||:|||||||||||||..|||...:||||||||||||||
  Fly   137 GLHLAEMCYRQYKRLPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTF 201

Human   183 FFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGI 247
            .|||||.|||||||..||.||||||::|||||:|:.|.||.:|.|:|:|.|..|....||||||:
  Fly   202 TFLFLDKYGLRKLEFLFGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGV 266

Human   248 VGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQ 312
            |||:|||||:||||||||||:|||.:...:.|||.||.|||::||.|||||||||:|||....|.
  Fly   267 VGAVIMPHNLYLHSALVKSRDIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYG 331

Human   313 KTNQAAFNICANSSLHDYAKIFPMNN----ATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQ 373
            |||.....:|.:.|:::.||:..::|    |.:..|:|:||:.|||.||..|:|||.:|:|||||
  Fly   332 KTNNDVVEVCKDKSMYEDAKMSFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQ 396

Human   374 SSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLL 438
            ||||||||||||.|||||.|:|.|:.|||:||..||:||..:|:|..:.||:.:||:||.:.||.
  Fly   397 SSTMTGTYAGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQ 461

Human   439 LPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALL 503
            ||||.:|.:.|||...:|.||.|||.||:|:..:.::|..:||||||..:.::....  ||.||:
  Fly   462 LPFAAIPTIAFTSCAAIMGEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIKG--GLLALV 524

Human   504 ---AAAYLGLSTYLV--WTCCLAH 522
               |..|:..:.|||  ...|:.:
  Fly   525 CIFAILYILFNLYLVIHMAACMGN 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC11A1	NP_000569.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		16/53 (30%)
		nramp	56..456	CDD:162246	257/403 (64%)
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	257/403 (64%)