DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC9A5 and Nha2

DIOPT Version :10

Sequence 1:NP_004585.1 Gene:SLC9A5 / 6553 HGNCID:11078 Length:896 Species:Homo sapiens
Sequence 2:NP_001247251.1 Gene:Nha2 / 42710 FlyBaseID:FBgn0263390 Length:714 Species:Drosophila melanogaster


Alignment Length:519 Identity:104/519 - (20%)
Similarity:187/519 - (36%) Gaps:143/519 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    26 SPGEPPPGLELFRWQW-----HEVEAPYLVAL-----------WILVAS-------LAKIVF-HL 66
            :||:...|.   :| |     |.|....||||           |:|:..       :.:|.| .:
  Fly   224 TPGDEYKGP---KW-WLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFV 284

Human    67 SRKVTSL------VPESCLLILLGLVLGGIV---LAVAKKAEYQLEPGTFFLFL----LPPIVLD 118
            ..:::.:      :|:     :||::..|::   |.:|....||    .|.|||    |..|:|.
  Fly   285 GAQISGILVTFVHLPD-----MLGMLFFGVLYANLGLANFEGYQ----KFELFLREMALINIMLL 340

Human   119 SG-----------YFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLL 172
            :|           :||..||..  |..|:..|.:..|.|...:...|||                
  Fly   341 AGLGLDGDAFKRLWFMILRLTL--LPTIVEVAAIAGLANLTLSMPWLWG---------------- 387

Human   173 DFLLFGSLISAVDPVAVLAVF-----EEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGS 232
              :..|.:|:||.|..|:.|.     :.:.:|..:..:::..:..||.|.:.::.|..|.:...:
  Fly   388 --IALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTT 450

Human   233 ANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRF-TKRVRIIEPLLVFLLAYAAYLTAEM 296
            :..|  ..|:|..        |..:||||.:|.....:: ..|.......|.|:|.......|.|
  Fly   451 SLTQ--QVLQGPI--------GIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVM 505

Human   297 ASLSAILAVTMCG-LGC---------------KKYVEANISHKSRTTVKYTMKTLASCAETVIFM 345
            .  |.::..|..| |||               .:.....:..:...:|...:..:....:.|.|.
  Fly   506 G--SRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFA 568

Human   346 LLG----ISAVDSSKWAWDSGLVL-GTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYG 405
            |:|    .:.:......:.:.||| |:|     ||.....|.|:..|      |.:.::..::..
  Fly   569 LIGKEINFNVLQGHVIGYGALLVLVGSL-----FRLAFAYLSTYGGN------LSRKERAYITIS 622

Human   406 GLRGAVAFALV--ILLDRTKVP----------AKDYFVATTIVVVFFTVIVQGLTIKPLVKWLK 457
            |...|...|.:  :.||..:..          |.:..:.:.:.::|...:...|.::....|||
  Fly   623 GFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIFTAPLGAILMLRLAPYWLK 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC9A5NP_004585.1 Na_H_Exchanger 41..630 CDD:470090 100/504 (20%)
Required for interaction with ARRB2. /evidence=ECO:0000269|PubMed:21296876 576..721
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..686
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..720
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..864
Nha2NP_001247251.1 NhaP 279..>686 CDD:439796 89/458 (19%)
Blue background indicates that the domain is not in the aligned region.

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