Protein Alignment SLC9A5 and Nhe2

DIOPT Version :10

• Sequence 1: NP_004585.1
• Gene: SLC9A5 / 6553
• HGNCID: 11078
• Length: 896
• Species: Homo sapiens
• Sequence 2: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Alignment Length: 1042
• Identity: 371/1042 - (35%)
• Similarity: 523/1042 - (50%)
• Gaps: 213/1042 - (20%)

Human    19 EPTQKPESPGEPPPGLELFRW-----QWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESC 78
            ||.:..:...:...|.::.|:     .:..|:.|:::.:|||.||:|||.||::.|:..:.||||
  Fly   163 EPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESC 227

Human    79 LLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGT 143
            |||::|:|:|.::......|...|.|.|||.::||||:||:|||||:||||||||.||..|||||
  Fly   228 LLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGT 292

Human   144 LWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFG 208
            ::|..|.|.:|:...:.|:.......||:|..||.|||||||||||||||||:||||.|:|:|||
  Fly   293 IFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFG 357

Human   209 ESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTK 273
            |||||||||||:|.:..|:.|:|...:.|.|...||.|.|||:|||.|:|:::.||..|.||||.
  Fly   358 ESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTD 422

Human   274 RVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASC 338
            .||:|||:.:|::||.|||.||:..:|.|||:|.||:..|.|||:|||.||.|||||.:|.|:|.
  Fly   423 HVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSS 487

Human   339 AETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMS 403
            |||:|||.||::.|::.. .|::..|:.|:.|...||.:||:|.:.:.|:|||..|.::||.|||
  Fly   488 AETIIFMFLGVATVNNMH-VWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMS 551

Human   404 YGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTL 468
            |||||||||||||:|:|...|..|:.||.|||.|::|||.:||:|||||||.|.|||:...|||:
  Fly   552 YGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTM 616

Human   469 NQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMR--RSAYRIRDQIWDVYYRL 531
            |:.:||...||::|.:||:||..|.:..||::::||.:::..||:|  :.|   ..:|.:.|.:|
  Fly   617 NERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGA---EPKIIETYSKL 678

Human   532 NIRDAISFVDQGGHVLSS-TGLTLPSMPSRNSV-----AETSVTNLLRESGSGAC---LDLQVID 587
            .:|||:..:.:....:.. ||....|...||..     ...|:|||     ...|   ||:..:|
  Fly   679 TMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNL-----DNTCSRNLDMAELD 738

Human   588 TVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTK 652
            ...|.:|..||.:||||...|...||..:.|.|||.:.:.....|.....|.|.:|   .|...|
  Fly   739 YNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRR---MFNDRK 800

Human   653 HNICFTKSKPRPRKTGRRKKDGVANAEA-TNGKHRGLGFQD------TAAVILTVESE------- 703
            |:              :|.|.|.:|.|| .|.|...:.|.|      |..:....||.
  Fly   801 HH--------------KRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKK 851

Human   704 -----------------EEEEESDSSETE------KED-DEGIIFVARAT--SEVLQEGKVSGSL 742
                             |..||...:..|      .:| |:|:.|.|:::  |:......:...:
  Fly   852 SYRKRHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRANNNSLIAHI 916

Human   743 EVCP---------------------------SPR----------IIP------------------ 752
            :..|                           ||.          |:|
  Fly   917 QNLPGFDASKARIVVQHYAPKADDNPDTDIESPEQAIGPTAAELILPWRRDRSYQSIVAEHPIPE 981

Human   753 ---------------PSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLA 802
                           .:||..|.:||||. |||       |.|..|..:....|   .|:.|.||
  Fly   982 EDRNLSRESDGERRVATPTATESQLPWKR-QGD-------ECTDAVQQNEFPAW---ASNKEYLA 1035

Human   803 SPPCNQAPILTCL-----PPHPR-------------------------------GTEEPQVPL-- 829
                ..:|..|.|     |..|:                               |:|...|.:
  Fly  1036 ----YNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSS 1096

Human   830 HLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGS 894
            ..|:.|.:|. ..|.|.|..:|.|.||......|     :|.:.|:...|.||:....::  |||
  Fly  1097 QPPNAPSTSI-HNPRLDKRSQSISSSSLGAGAHQ-----LGPEGHSGPFPVTASHRRNVR--RGS 1153

Human   895 RL 896
            .|
  Fly  1154 ML 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC9A5	NP_004585.1	Na_H_Exchanger	41..630	CDD:470090	286/599 (48%)
		Required for interaction with ARRB2. /evidence=ECO:0000269|PubMed:21296876	576..721		45/185 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..686		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..720		7/49 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..864		14/78 (18%)
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	260/518 (50%)