Protein Alignment SLC9A5 and Nhe1

DIOPT Version :10

• Sequence 1: NP_004585.1
• Gene: SLC9A5 / 6553
• HGNCID: 11078
• Length: 896
• Species: Homo sapiens
• Sequence 2: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 166/539 - (30%)
• Similarity: 269/539 - (49%)
• Gaps: 70/539 - (12%)

Human    42 HEVEAPYLVAL----WILVASLAKIVFH-LSRKVTSLVPESCLLILLGLVLGGIVLAVAK----- 96
            |.||..:..:|    .|.|..|..::.| :.:.....:|||.:::.||..: |:.|.|..
  Fly    92 HAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFI-GLSLNVMSGQNGS 155

Human    97 -KAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQA 160
             |.|....|..|||.|||||:.:|||.:....||.|:|:||.:|:.||..:|...||.:: |...
  Fly   156 WKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-LLGL 219

Human   161 GLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCN 225
            |.||.|:  ...:...||||||||||||.:|:|..:.|:..|.::|||||:||||:::||   ..
  Fly   220 GEVAFRL--SFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVL---TA 279

Human   226 SFVEMGSANVQAT------DYLKGVASLFVVSLGGAAVGLVFAFLLALTTRF--TKRVRIIEPLL 282
            |..:..:.|.:|:      ..||...::|..|.|   :|::||.:.||..:.  .::...:|..:
  Fly   280 SITQSANVNAEASTGEAMFSALKTFCAMFFASAG---IGVIFALISALLLKHIDLRKHPSLEFAM 341

Human   283 VFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLL 347
            :.:..||.|:.||...||.|:|:..||:....|...|:|..::.|::.||:|||..|||.:|..|
  Fly   342 MLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYL 406

Human   348 GISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVA 412
            |: |:.|.|...:...|:..::..|..||..:....:::|:||...::...|.:|.:.|||||::
  Fly   407 GL-AIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAIS 470

Human   413 FALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKV------------------- 458
            :||.:.|:......:...:.||:::|.||.:|.|.:..||:|:||.
  Fly   471 YALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGR 535

Human   459 ------KRSEHHKPTLNQEL-----HEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLL 512
                  |||:....:..:|.     .||..:  |...|||.    :...|||:.:.|:||.....
  Fly   536 RNGSGRKRSKSISLSKTREWGQAIDSEHLSE--LTEEEDVT----FTQARDRFGRMDRKYFIPFF 594

Human   513 MRR----SAYRIRDQIWDV 527
            .||    ..:..:.|:.|:
  Fly   595 TRRFNSQELHECKSQMADL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC9A5	NP_004585.1	Na_H_Exchanger	41..630	CDD:470090	166/539 (31%)
		Required for interaction with ARRB2. /evidence=ECO:0000269|PubMed:21296876	576..721
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..686
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..720
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..864
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	156/502 (31%)