Protein Alignment BMP7 and scw

DIOPT Version :10

• Sequence 1: NP_001710.1
• Gene: BMP7 / 655
• HGNCID: 1074
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 436
• Identity: 131/436 - (30%)
• Similarity: 209/436 - (47%)
• Gaps: 70/436 - (16%)

Human    21 LFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPR----PHLQGKHNSAPM 81
            ||...||....:.:|.:......:|..|:     |.|::.||.|..|||    |:|   ||||..
  Fly    10 LFYAASATTYVTTNNHIEMPIYQKRPLSE-----QMEMIDILDLGDRPRRQAEPNL---HNSASK 66

Human    82 FMLDLYNAMAVEEGGGPGGQGFSYPYKAVF-----STQGPPLASLQDSHFLTDADMVMSFVNLV- 140
            |:|::||.::.::          .|.:.:.     |.....|.|.:|...:...:.:::|.:.:
  Fly    67 FLLEVYNEISEDQ----------EPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRLK 121

Human   141 --EHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKD-YIRERFDNETFRISVYQVLQEHL 202
              :.|.|.      .....|:.:.:|...::..|..||||. .:.:|..|  |.:|||:.|...
  Fly   122 PEQLDNEL------DMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRAN--FTVSVYRKLDNR- 177

Human   203 GRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQ----LSVETLDGQSINPKLAG 263
             ::....:|.|....:|:.|||.|::|.|..:|:    ||.|||    |.:...|.| ::...||
  Fly   178 -QDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWL----HNKGLQRRNELRISIGDSQ-LSTFAAG 236

Human   264 LIGRHGPQ----NKQPFMVAFFKATE--VHFRSIRSTG--SKQRSQNRSKTPKNQEALRMANVAE 320
            |:   .||    :.:||:|.:|...|  |..:.:|...  .|:|:...|..|.....:.:..
  Fly   237 LV---TPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYR--- 295

Human   321 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHF 385
                 ..|:|::....|.|::|...:|:|||:.:.||:|.|.|.|||.:.||||||||||||:|.
  Fly   296 -----PPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHL 355

Human   386 INPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 431
            ..|. :|||||.||.|.||::|.:.:...:.|.||:..|.:.||||
  Fly   356 KQPH-LPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:459906	69/265 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..311		5/21 (24%)
		TGF_beta_BMP7	325..431	CDD:381667	48/105 (46%)
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	66/245 (27%)
		TGF_beta_BMP5_like	299..400	CDD:381639	47/101 (47%)