Protein Alignment BMP7 and myo

DIOPT Version :10

• Sequence 1: NP_001710.1
• Gene: BMP7 / 655
• HGNCID: 1074
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 105/512 - (20%)
• Similarity: 182/512 - (35%)
• Gaps: 166/512 - (32%)

Human     6 LRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREI-------LSILG 63
            |...:.|..::....:.|.|:.|.:.       .|.:.|:||.:.:.:....|       |::..
  Fly   165 LAKVSEHGDLSRVQSVSLYRNTLINI-------ESMLQRQLREKAKVDSIESIKMHILMRLNLKK 222

Human    64 LPHRPRPHLQGKHNSAPMFMLDL----YNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDS 124
            ||:..:|      .|.|..::|.    |||.:.                   :|....:.|:.:|
  Fly   223 LPNITKP------ISVPQNIIDNFYRDYNASSK-------------------TTVWNRMESIDES 262

Human   125 HFL---TDADMVMSFVNLVEHDKEFFHPRYHHR----------EFRFDLSK-------IP----- 164
            |..   |..|.:|:         :||......:          ||..||:|       ||
  Fly   263 HLSINDTYGDHIMT---------DFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTND 318

Human   165 -EGEAVTAAEFRIY------KDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEG 222
             |.|::.:....||      :.::|.....:.||..:          :|....|...||.....|
  Fly   319 EEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQI----------DSSYSDLSYATLHLYLRG 373

Human   223 WLVFDITATSNHWV------------VNPRHNLGLQL--SVETLDGQSINPK------------- 260
            |          .|:            ..||.::.:.:  ::...:..|.|||
  Fly   374 W----------DWISAHQPGLLEEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSG 428

Human   261 --------LAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTP---------K 308
                    |..|:|..|....|..::   |..|...:|:..|     :.|.||.|         :
  Fly   429 LGQWVAVDLKSLLGNLGSNMTQEILI---KGAETWMKSLVVT-----TDNTSKNPLTVHIEIGSQ 485

Human   309 NQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNA 373
            .:...:.:...:.:.:|....|.::.|.|:|...||. :::||..:.||:|.|:|..   .|:..
  Fly   486 KKHRRKRSVYMDCTENDHDMRCCRYPLKVNFTSFGWH-FVVAPTSFDAYFCSGDCKV---GYLEQ 546

Human   374 TNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
            ..|      .|.....|...|||:||:::::|:|||||:.|::|....||.|..|.|
  Fly   547 YPH------THLAALTTSATPCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSC 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:459906	56/322 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..311		5/28 (18%)
		TGF_beta_BMP7	325..431	CDD:381667	36/106 (34%)
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	34/100 (34%)