Protein Alignment BMP7 and gbb

DIOPT Version :10

• Sequence 1: NP_001710.1
• Gene: BMP7 / 655
• HGNCID: 1074
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Alignment Length: 444
• Identity: 162/444 - (36%)
• Similarity: 233/444 - (52%)
• Gaps: 40/444 - (9%)

Human    14 FVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRP---RPHLQGK 75
            |||...|  .:.:..:...:||....:.:||.|...::.::..|||..||:..||   ..|....
  Fly    26 FVATTPP--AVEATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLGIAERPTHLSSHQLSL 88

Human    76 HNSAPMFMLDLYNAMAVEEGGGPGGQGFSYP--YKAVFSTQGPPLASLQDSHFLTD--------A 130
            ..|||.|:||:|:.:..|||.....:...|.  :::..|.........|..:|:||        :
  Fly    89 RKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQKNFITDLDKRAIDES 153

Human   131 DMVMSFVNLVEHD-KEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERF--DNETFRI 192
            |::|:|:|...|: .|..|.  |.|...||:|.:|....:..||.|||::....::  .|..|.|
  Fly   154 DIIMTFLNKRHHNVDELRHE--HGRRLWFDVSNVPNDNYLVMAELRIYQNANEGKWLTANREFTI 216

Human   193 SVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSI 257
            :||.:....||:.: :..|.|........|||..::|...:.|:|..:.|.|:.:....::....
  Fly   217 TVYAIGTGTLGQHT-MEPLSSVNTTGDYVGWLELNVTEGLHEWLVKSKDNHGIYIGAHAVNRPDR 280

Human   258 NPKL--AGLIGRHGPQNKQPFMVAFFKATEV--------HFRSIRSTGSKQRSQNRSKTPKNQEA 312
            ..||  .|||.|......||||:.||:..|:        |.||.|| .|..|.:.:|.:|.|...
  Fly   281 EVKLDDIGLIHRKVDDEFQPFMIGFFRGPELIKATAHSSHHRSKRS-ASHPRKRKKSVSPNNVPL 344

Human   313 LRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHA 377
            |        ...:..::|:...||:.|:||||.|||||||||.|:||.|||.||||::|||||||
  Fly   345 L--------EPMESTRSCQMQTLYIDFKDLGWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHA 401

Human   378 IVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 431
            |||||||.:.|:.|||||||||:|.|:.|||..:..||.|||||||:|::||||
  Fly   402 IVQTLVHLLEPKKVPKPCCAPTRLGALPVLYHLNDENVNLKKYRNMIVKSCGCH 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:459906	73/262 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..311		7/19 (37%)
		TGF_beta_BMP7	325..431	CDD:381667	68/105 (65%)
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	73/262 (28%)
		TGF_beta_BMP5_like	353..455	CDD:381639	68/101 (67%)