Protein Alignment BMP7 and dpp

DIOPT Version :10

• Sequence 1: NP_001710.1
• Gene: BMP7 / 655
• HGNCID: 1074
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 500
• Identity: 135/500 - (27%)
• Similarity: 206/500 - (41%)
• Gaps: 155/500 - (31%)

Human    43 HRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSA-----------------PMFMLDL---- 86
            |.::..:|:|...::       .|..|.| |.|..||                 |..:||.
  Fly   131 HNKMAVKEQRSHHKK-------SHHHRSH-QPKQASASTESHQSSSIESIFVEEPTLVLDREVAS 187

Human    87 ----YNAMAVEEGGGPGGQGFSYPYKA----------------------VFSTQGPPLASLQDSH 125
                .||.|:....||.    :|..:|                      :|:.:.||  .:..|.
  Fly   188 INVPANAKAIIAEQGPS----TYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPP--KIDRSK 246

Human   126 FLTDADMVMSFVNLVEHD-------------------KEFFH------PRY-HHREFR--FDLSK 162
            .:....|...:..::.|:                   :.|.|      .|: ||..||  ||:..
  Fly   247 IIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKS 311

Human   163 IPEGEAVTAAEFRIYKDYI-------RERFDNETFRISVYQVLQEHLG----RESDLFLLDSRTL 216
            ||..|.:.|||.::.:|.:       |...:...:::.||.:.:  :|    ||....|||::|:
  Fly   312 IPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITR--VGVRGQREPSYLLLDTKTV 374

Human   217 WASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGP----------- 270
            ..:....:..|:....:.|:.:|:.|.||.:.|.|:  :|:.|         .|
  Fly   375 RLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTV--RSLKP---------APHHHVRLRRSAD 428

Human   271 ------QNKQPFMVAFFKATEVHFRSIRST---------GSKQRSQNRSKTPKNQEALRMANVAE 320
                  |:|||.:..:........||||..         |..:|...|....||.:
  Fly   429 EAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHD--------- 484

Human   321 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHF 385
                   ..|::|.|||.|.|:||.|||:||.||.||||.|:|.|||..:.|:||||:|||||:.
  Fly   485 -------DTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNN 542

Human   386 INPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
            :||..|||.||.||||:::::||.:|.|.|:||.|:.|.|..|||
  Fly   543 MNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:459906	67/339 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..311		7/28 (25%)
		TGF_beta_BMP7	325..431	CDD:381667	58/105 (55%)
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	47/233 (20%)
		TGF_beta_DPP	480..588	CDD:381662	60/123 (49%)