Protein Alignment SLC8A3 and Calx

DIOPT Version :10

• Sequence 1: NP_892114.1
• Gene: SLC8A3 / 6547
• HGNCID: 11070
• Length: 927
• Species: Homo sapiens
• Sequence 2: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Alignment Length: 937
• Identity: 445/937 - (47%)
• Similarity: 604/937 - (64%)
• Gaps: 100/937 - (10%)

Human    36 GDVPSTGQNNESCSGSSDCKEGVILPIWYPE-NPSLGDKIARVIVYFVALIYMFLGVSIIADRFM 99
            |:.|...:..|       |.||::||:|.|: |.|:||::.|..||||.|||:|:||||||||||
  Fly    89 GEAPDAEELRE-------CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFM 146

Human   100 ASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGD 164
            |:||.|||.||.|.:|.||.......:|:|||||:|||||||||||||||||:||:....|.:||
  Fly   147 AAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGD 211

Human   165 LGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVV 229
            |||.|||||||:|:|:||.:|:..||.||.|:|:||||||:||.:|:|||:||::||:||:|||:
  Fly   212 LGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVI 276

Human   230 QVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGK---- 290
            .|||.::||.|||:.||.|::|::|||.||||.|.||.:| ||.::..|.|.   :|||.:
  Fly   277 LVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVAGEHDQ---VEMDAEKGPK 337

Human   291 --MMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAF 353
              |:.|  ..||    :.:..||:|||.|.:|.:|:||:|:.||:||..||....|:...|||||
  Fly   338 QPMVTS--ARGN----DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAF 396

Human   354 YRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHT------DEPEDFISKVFFDPCSYQCLENCG 412
            |||||||.|.|:||:::|   .|.:..|.::||..      ||..|...:::|:|..|..:||||
  Fly   397 YRIQATRKMVGSGNLMRK---IQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCG 458

Human   413 AVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEED 477
            ...:.|||: ||:|....|:|:|:||:|:||.|:...:|.:...||..::.|.:.:||||:||||
  Fly   459 EFEVRVVRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEED 522

Human   478 EHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVS 542
            |.|::||.|       |.||:.             ||.|.:|||.||||||||||.|......::
  Fly   523 ECFYIRLFN-------PSEGVK-------------LAVPMIATVMILDDDHAGIFAFTDSVFEIT 567

Human   543 ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEE 607
            ||:|..|:||:|.||||||||||:.|...||. ..:|:|...|||.|:|:|:.|.|.:.|::|..
  Fly   568 ESVGRFELKVMRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESS 631

Human   608 YERQENFFIALGEPKWMERGISALLLSPDVTDRKL---------------TMEEEEAK------- 650
            ||:..:|.:.:|||:          |:||.|:::.               |.:|..||
  Fly   632 YEKDVSFKVHIGEPR----------LAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKK 686

Human   651 ---------RIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAI 706
                     ||..:.||..||.....|.|.||.|||.|||||:.|.|::.|:||.||::||.:|:
  Fly   687 PVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDAL 751

Human   707 TVSAAGDEDE--DESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLT 769
            ||..| ||.|  ::..||.:||||.||.||:.:|||||||.||||:.|.|:..|.|||.:||::|
  Fly   752 TVIPA-DESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVIT 815

Human   770 AIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFL 834
            |||||.||:|||.:.:||||||::|||.|||:||||||..||..|..||..||||||||||||||
  Fly   816 AIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFL 880

Human   835 GIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR-RPHLGGELGGPRGCK 898
            ||||||::||:|.:..|..|:|..||:.|:|.||...|.:.|.::::|| ...:|.|||||:..|
  Fly   881 GIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSK 945

Human   899 LATTWLFVSLWLLYILFATLEAYCYIK 925
            ..:..:.|.||:.|::...||||..|:
  Fly   946 YISAAILVFLWVFYVVICILEAYDVIR 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC8A3	NP_892114.1	caca	1..927	CDD:273296	445/937 (47%)
		Alpha-1	140..180		28/39 (72%)
		Putative calmodulin-binding region. /evidence=ECO:0000250|UniProtKB:P23685	253..272		11/18 (61%)
		Alpha-2	796..832		25/35 (71%)
Calx	NP_001247215.1	caca	4..973	CDD:273296	445/937 (47%)