Protein Alignment SLC7A4 and CG13248

DIOPT Version :9

• Sequence 1: NP_004164.2
• Gene: SLC7A4 / 6545
• HGNCID: 11062
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_649219.1
• Gene: CG13248 / 40254
• FlyBaseID: FBgn0036984
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 637
• Identity: 273/637 - (42%)
• Similarity: 387/637 - (60%)
• Gaps: 50/637 - (7%)

Human    11 LARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSF 75
            |:.:|.|:||.|.:....|||.|.|||:|.|:.|||:|.|||:|:|||||.||||:|||.::|||
  Fly    13 LSGICTKMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSF 77

Human    76 GVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGY 140
            .:|...|:||||||||||.|||:.||||::||:||||.|||:||||:|||:::|.|:||||||||
  Fly    78 ILAGFISMLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGY 142

Human   141 LDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLV 205
            :|||....|.|.|....|....|.|..|||.||..:.::.:|.::.|.:.::..|...:.:::.|
  Fly   143 VDSMLGGWIGNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAV 207

Human   206 ILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPL 270
            ::.::.:||..|...|||..||||.|:|..||:||.|:|||||||||.||.|.|||:||..|:|:
  Fly   208 MVLVISVGFWYADGKNWSEAEGGFLPYGVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIPV 272

Human   271 AIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLS 335
            |..|||.:....|||||..||||:|...::|.::|.:||.|....||.::::.|::|.|.|.||.
  Fly   273 ATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKYLISIGALCGMTTTLLG 337

Human   336 LLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLL 400
            .||:|||.:||||:|||.|..|..::|.||||:...:..|:::|.|||:.||..||:|:|:||||
  Fly   338 SLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVEFMSIGTLL 402

Human   401 AYTFVATSIIVLRFQ--------------KSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHAS 451
            |||.|:.|:|:||::              ..||.................:.|...:::..|.|
  Fly   403 AYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSEMIEEVLA- 466

Human   452 VPEPGELKPALRPYLGFLDGYSPGAVVTWA--LGVMLASAITIGCV-LVFGNSTLHLPHW----- 508
                |.||...|.....|..:.||:||:.|  |.:.|:.||   || |....:.|:...|
  Fly   467 ----GRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAI---CVELKVSWTQLYTGTWWALII 524

Human   509 -GYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFS 572
             |:|:....|.|      .|:..|.|..|..:|::|:||.:|||.|..||.||:.|..:|||||.
  Fly   525 YGFIIFAAGTCV------AVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHLDAVTWVRFF 583

Human   573 IWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVF--------PRGSLEET 616
            :|:.:|:.|||.||||:|||.:     :.|::.::.        |.||.:.|
  Fly   584 VWVCIGMVVYFLYGIRNSKEGE-----VCSSYSILMTTSEAGKVPWGSFKAT 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC7A4	NP_004164.2	2A0303	26..592	CDD:273330	260/588 (44%)
		AA_permease_C	540..590	CDD:290617	27/49 (55%)
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	259/584 (44%)
		AA_permease_C	551..601	CDD:290617	27/49 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I713
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20883
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1370
Isobase	1	0.950	-	0	Normalized mean entropy	S2810
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D290636at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		oto89441
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	LDO	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.860