Protein Alignment SLC8A2 and Calx

DIOPT Version :10

• Sequence 1: NP_055878.1
• Gene: SLC8A2 / 6543
• HGNCID: 11069
• Length: 921
• Species: Homo sapiens
• Sequence 2: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Alignment Length: 899
• Identity: 431/899 - (47%)
• Similarity: 592/899 - (65%)
• Gaps: 54/899 - (6%)

Human    49 CQPGVLLPVWEPD-DPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKA 112
            |..|::||:|.|. :.|:||:..|..||||.::|:|:||||||||||||||.|||.|:.:.:...
  Fly   100 CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGP 164

Human   113 NGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVI 177
            |....|..||||||||:||||||||||||||||||||:...:|::|:|||||||||||:|:|::|
  Fly   165 NNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMII 229

Human   178 AVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVF 242
            |||:..|||||.|:|:|||||||||.:|:||||||:|||:||:|||:.||||::||:|||:.|::
  Fly   230 AVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLW 294

Human   243 AWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARE 307
            |::|::|||.|||:.|.||.:.| |.::..|.|   .:|:|.. .|.:.|......|   .:|..
  Fly   295 AYIAERRLLVYKYMDKNYRVNKR-GTVVAGEHD---QVEMDAE-KGPKQPMVTSARG---NDAEA 351

Human   308 LDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLR--- 369
            .|.:|||.|.:|.:|:||:||.|||||..:|....|....||||||||||||.|.|:||::|
  Fly   352 FDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQ 416

Human   370 -RHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTF-YVDYR 432
             |..:|.:...|......::|.|...|::|||..|..:||||...:.|..:|  ..||: .|:|.
  Fly   417 ERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG--DISTYASVEYE 479

Human   433 TEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPD 497
            |:||:|.||:|:...:|.|.|.||..::..||.:||||:|||||.|::||.|    .::|:
  Fly   480 TQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFN----PSEGV---- 536

Human   498 GGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTV 562
                   :|..|::|||.||||||||||:|.|.:..::|.:|..:::|:|.|||||||.:||.|.
  Fly   537 -------KLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTE 594

Human   563 DGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQ----------WL 617
            :.||. ....||.|.|||.|.::|:.|.:.:.|:::..|||..:|.:.:|:|:          :.
  Fly   595 NDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFF 658

Human   618 KRGI-----------SALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKN 671
            .|..           ..|.....:.::|...:..|..||..:.||..||.....|.|.||.:||.
  Fly   659 NRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKA 723

Human   672 TVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVL 736
            |||||:.|.|::.|:||.||:|||.:|:||...||.|.::...||.:||||.||.||:.:|||||
  Fly   724 TVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVL 788

Human   737 FACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFAS 801
            ||.||||:.|.|:..|.|||.|||::||:|||.||:|||.:.:||||.|::||||||||||||||
  Fly   789 FAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFAS 853

Human   802 KVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFA 866
            .:||..|:.||..|||||||||||||||:|:||::||||.:..|..|.|..||:.|:|.||...|
  Fly   854 MIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEA 918

Human   867 FVGIAVLLYRR-RPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIR 919
            .:.|.::::|| ...||.|||||:..|..:.|:.:.||:.|::...||||..||
  Fly   919 LIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVIR 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC8A2	NP_055878.1	caca	1..921	CDD:273296	431/899 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..42
		Alpha-1	135..175		29/39 (74%)
		Putative calmodulin-binding region. /evidence=ECO:0000250|UniProtKB:P23685	248..267		10/18 (56%)
		Alpha-2	790..826		27/35 (77%)
Calx	NP_001247215.1	caca	4..973	CDD:273296	431/899 (48%)