Protein Alignment SLC7A2 and CG13248

DIOPT Version :9

• Sequence 1: NP_001158243.1
• Gene: SLC7A2 / 6542
• HGNCID: 11060
• Length: 698
• Species: Homo sapiens
• Sequence 2: NP_649219.1
• Gene: CG13248 / 40254
• FlyBaseID: FBgn0036984
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 260/617 - (42%)
• Similarity: 363/617 - (58%)
• Gaps: 53/617 - (8%)

Human    56 RRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASV 120
            |.|.|..|.:| |.|.|||:|.|:..||:|..:|||:|||.|.|||..:||.|::||::|...|:
  Fly    22 RTKSVPTDVME-TPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSFILAGFISM 85

Human   121 MAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQ 185
            :|.|||||||.||||.||||:|||:::||.|||:.|||::|.:::|.:||||||||..|.:|...
  Fly    86 LAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLEHMLGAASVARAWSGYVDSMLGGW 150

Human   186 IGQ-FLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAG 249
            ||. .|.....::..|||:|||..|..:.::.|..|:.|||.:|..|.:.|.|||.|::.|:..|
  Fly   151 IGNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVMVLVISVG 215

Human   250 FVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCI 314
            |...:..||..:|                        |||:|||..|.:||||||||||||||.|
  Fly   216 FWYADGKNWSEAE------------------------GGFLPYGVGGVIAGAATCFYAFVGFDSI 256

Human   315 ATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKY 379
            ||:|||.:||..:||:..|.||.|..:.|..||||||||:|...::..:.||.||..:....|||
  Fly   257 ATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPISEINPAASLPEAFGQLNLSWAKY 321

Human   380 VVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFL 444
            :::.|:||.::|:||||:|.:||.:||||.|||||.|..:||..|:.|::..:.||.::|.:|.:
  Fly   322 LISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALV 386

Human   445 FDLKALVDMMSIGTLMAYSLVAACVLILRYQP--------------GLSYDQPKCSPEKDGLGSS 495
            |||..||:.||||||:||::|:|.|:||||:|              |...|..  ..::|....|
  Fly   387 FDLAKLVEFMSIGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDDD--DDDEDVASQS 449

Human   496 PRVTSKSESQV---TMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVH 557
            ...||...|::   .:..|.....|.|  ..||...:..|:||  |..:.|:.|..::.....|
  Fly   450 SMDTSSPTSEMIEEVLAGRLKAQFRCL--EPLLGRFEPGSVVS--VAVMLFIFLSFAICVELKV- 509

Human   558 AITRLEA---WSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQL 619
            :.|:|..   |:|.:....:......|..|....||.:.:.|.||.:||:||..|..||.|||.|
  Fly   510 SWTQLYTGTWWALIIYGFIIFAAGTCVAVIAVHNQNTRGLIFKVPLVPFVPALGIFCNILLMVHL 574

Human   620 SADTWVRFSIWMAIGFLIYFSYGIRHSLEGHL 651
            .|.|||||.:|:.||.::||.||||:|.||.:
  Fly   575 DAVTWVRFFVWVCIGMVVYFLYGIRNSKEGEV 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC7A2	NP_001158243.1	2A0303	45..648	CDD:273330	258/612 (42%)
		AA_permease_C	596..646	CDD:290617	29/49 (59%)
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	254/602 (42%)
		AA_permease_C	551..601	CDD:290617	29/49 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680