Protein Alignment SLC6A13 and GlyT

DIOPT Version :9

• Sequence 1: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 249/618 - (40%)
• Similarity: 362/618 - (58%)
• Gaps: 67/618 - (10%)

Human     1 MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKN 65
            :|:...|....||::.              |||.|..:.:|:||:.|..:|||||||||||||.|
  Fly    40 LDATGPGAGGAGESEH--------------ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNN 90

Human    66 GGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYI 130
            |||||.||:.:.|...|:|:..:|.:.|||.:.|.|..:|:.||:|.|:|....::..::.:||.
  Fly    91 GGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYN 155

Human   131 IVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEF------QKTNGSLN-GTSENATS------- 181
            :::||.:||:|:||...|||..|...|:|::|..:      :.|||:.. .|..||||
  Fly   156 LIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNIT 220

Human   182 ----------PVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYF 236
                      |..|::...||.:|.||:..|:::..||.||.|||.|.:.|:.|||:|:||||||
  Fly   221 TLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYF 285

Human   237 TATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALG 301
            ||.|||::||:|.:||||||||:.||.|||.|:..:|.:.|||.||..||||:.:...|.|..|.
  Fly   286 TALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLS 350

Human   302 SYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV 366
            ||||:.||||:|.:.:.|.|..|||.||..||||:||::.|..|.:.:|.:.|.|||||.||..|
  Fly   351 SYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVV 415

Human   367 VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVG 431
            ..||.||:||..||.|::.|||||||..:|::.||::|.:|::   :..:..::|.|::..::.|
  Fly   416 TRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNL---RQYKIWVVLSVAIFGYIGG 477

Human   432 LIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKY-- 494
            |...|..|||..||.|.|||:...|| :||.|.:.:||:||::||.::|:.|||.|.|....:
  Fly   478 LGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWG 541

Human   495 -CWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCI------PAWSLYR 552
             .|.::|||.......|:.::|.|..|. .|.||.|.||:||::.|..::.|      ..|
  Fly   542 IMWRYITPATLLFILFFNWVEYKPAKYG-HYVYPMWADAVGWIVGLLPVLVIFLVAFQEIW---- 601

Human   553 LGTLKGP----FRERIRQLMCPAEDLPQRNPAG 581
                :.|    ||:||:.|:.|..:.   .|||
  Fly   602 ----RAPMSLSFRDRIKHLLQPTAEW---GPAG 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/20 (20%)
		SLC6sbd_GAT2	32..575	CDD:271396	241/579 (42%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	234/558 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820