DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A13 and CG8850

DIOPT Version :9

Sequence 1:	NP_057699.2	Gene:	SLC6A13 / 6540	HGNCID:	11046	Length:	602	Species:	Homo sapiens
Sequence 2:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	197/530 - (37%)
Similarity:	303/530 - (57%)	Gaps:	14/530 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    25 EEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLE 89
            |.:.:.:|..|:..:||:.|.....:|||||||||::..:||||||.|||::.|...|.||:.||
  Fly    50 ESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLE 114

Human    90 TALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCY 154
            ..:||::|:|.:.|: .:.||..||.|.......|...||..::|..:.||.:||:..|||..|.
  Fly   115 VIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCL 178

Human   155 HEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQH--LGALRWELALCLLLAWV 217
            .||. :.|:....|..:.:...:..:|..: |:.:.||:..:.:..  ||...|:|.||||..||
  Fly   179 VEWG-KSCVATGATAANDSSIVQGVSSAEL-FFTQTVLREPESLDDNGLGTPSWDLVLCLLATWV 241

Human   218 ICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDA 282
            |....:.||::|:||..||.|.|||::::|||||.||||||.|||.::|.|..::|.:|.||..|
  Fly   242 IIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAA 306

Human   283 GTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGV-P 346
            .||:|||.|||.|.|....|:|.::.|.::|.|.:..::|.||.:||..||.|||.::.|... .
  Fly   307 ITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKD 371

Human   347 ISEVAESGPGLAFIAYPRAVVMLPFSP-LWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410
            ||:|.:.|.|||||:||.|:....:.| |:|..||||:::||:.|......::|..:.|.:.|:
  Fly   372 ISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHL- 435

Human   411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKR 475
                ...:|.:..|::.||.||:.:|.||.:|..|.|:|..:.:.|: :||.|.|.|.|:||.||
  Fly   436 ----PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAVGWIYGVKR 495

Human   476 FYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS 540
            ...:||.|:..:.....:.||..:.|.:.....::.|..|.|||| :...||......||::...
  Fly   496 ICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTY-RGVQYPPVYYMAGWIIWGL 559

Human   541 SMVCIPAWSL 550
            .::.:|.|:|
  Fly   560 GVLQLPFWAL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
SLC6A13	NP_057699.2	SLC6sbd_GAT2	32..575	CDD:271396	196/523 (37%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	182/482 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820