Protein Alignment SLC6A12 and Gat

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Alignment Length: 573
• Identity: 301/573 - (52%)
• Similarity: 405/573 - (70%)
• Gaps: 24/573 - (4%)

Human    31 DQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVA 95
            :|:.|||.|::||:|:|||.|..|||||||||||||||||||||.:||.|..|:.|||:||:|:|
  Fly    53 EQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELA 117

Human    96 LGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF 160
            |||..:.|.:..: ||.|:|:|||.|:.|:..::|||||:|||||:||.|.|..:::||.||||:
  Fly   118 LGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNW 181

Human   161 WNTE-----------HCTD-FLNHS-------GAGTVTPFENFTSPVMEFWERRVLGITSGIHDL 206
            |||.           ||.| .:|.:       .|..:|..| .|.||.||||||.|.|:.||.::
  Fly   182 WNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLE-LTDPVKEFWERRALQISHGIEEI 245

Human   207 GSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYL 271
            |::|||||..|||.|::||||||||||.|||||||||.|||::|.|||:||:|||||.:||.:|:
  Fly   246 GNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYI 310

Human   272 KPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFV 336
            .|:..:|.:.:||:||.||||||:.:..|.|.|||||||:.||.|||.:.:|.:||:||..||||
  Fly   311 IPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFV 375

Human   337 VFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVE 401
            :||::|||:.||..|:::||.|||||||:.:|.||..:|.|.:||||||.||:.:||||||..:|
  Fly   376 IFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTME 440

Human   402 CLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSL 466
            ..:||.||.:|:.|||  |:|:.|..:..:.||:||..:|:|||||||:.|.||.||.|||:|..
  Fly   441 GFITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIF 503

Human   467 FEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVY 531
            ||.|.|||.||.|||||.|:|||||.|....|..|...||.:||..|.|::.::||:||.: |.|
  Fly   504 FECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSY 567

Human   532 PPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQ 584
            |.|.::.|||.|||||:.:||::.....:|.|...:::|.|:..|..:.:.::
  Fly   568 PWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDEDVTRLRE 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	299/558 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		1/9 (11%)
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	298/557 (54%)