Protein Alignment SLC6A12 and CG4476

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 588
• Identity: 201/588 - (34%)
• Similarity: 321/588 - (54%)
• Gaps: 59/588 - (10%)

Human    34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQ 98
            |.|..|.:.:||::|.....:|||||||||:...:||||||.|||.:..||.|.|::::|:.|||
  Fly    49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQ 113

Human    99 YTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNT 163
            ::|:|.|..: ...||.:|:|.|.::....|..||..::|..|.|.|.||.|||||:.|...|
  Fly   114 FSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEW-- 175

Human   164 EHCTDFLNHSGAGTVT-----PFE-----NFTSPVMEFWERRVLGITSGIHD-LGSLRWELALCL 217
                      |.|.|:     |.:     ||:|....:.:|.||..|..:.: :|.....|||.|
  Fly   176 ----------GDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALML 230

Human   218 LLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQ 282
            .::|:.....|.:||||:||..|..|.|||:::.|||:|.:||||||.|::|:|.|...:|.:||
  Fly   231 GISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQ 295

Human   283 VWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQE 347
            ||.:|.||:|||.|:|.|.:....|||::.:|.|:|...:..|::.||.::|.::|.|||.::.|
  Fly   296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHE 360

Human   348 QGV-PISEVAESGPGLAFIAFPKAVT---MMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASI 408
            .|. .|:.|.::|||||||::|.|:.   |.|  |::|.|||.||..||:.|....|.|::|...
  Fly   361 SGTKDIASVVKAGPGLAFISYPDAIAKFKMFP--QVFSLLFFAMLFMLGVGSNVGMVSCIMTVLK 423

Human   409 DMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCIS 473
            |.|     .:.:..:::::::|:.:|:||..:|.||.:|..|.|::..:.:.|: .::||::.:.
  Fly   424 DQF-----VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVG 482

Human   474 WVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSI 538
            |:||..|...:.|.|:..:.....:|.|..:||.:.|...::||....||.||. ..:|.....:
  Fly   483 WIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNG-QEFPLVYRVV 546

Human   539 GWFLALSSMVCVPLFV---VITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 600
            ||  .:|..:...||.   .....:.:|..:.|:...|.|.|                 ::|||.
  Fly   547 GW--CVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHS-----------------DWGPSD 592

Human   601 TRE 603
            .::
  Fly   593 PKK 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	195/557 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		4/28 (14%)
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	179/494 (36%)