Protein Alignment SLC6A12 and DAT

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 264/583 - (45%)
• Similarity: 370/583 - (63%)
• Gaps: 41/583 - (7%)

Human    29 DEDQVKD-RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFL 92
            |.:.:.| |..|:.|::|:|||.|..:.|.|||||||||||||||||.:||.|...|.|||:|::
  Fly    19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYM 83

Human    93 EVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTC 157
            |:||||:..:|::|.|.::.|||:|||.|.|:|..|::.||.:|:||:|.:.|:|||:.||||:|
  Fly    84 ELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSC 148

Human   158 NNFWNTEHCTDF-------------------------------LNHSGAGT--VTPFENFTSPVM 189
            ||.|||.:|..|                               :|.|...|  |...|.|.|...
  Fly   149 NNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS 213

Human   190 EFWERRVLGI--TSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVI 252
            |::.|.:|.:  :.||||||:::|::|||||:.::||||.:|||:.::||||:|||.|||.:|:|
  Fly   214 EYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLI 278

Human   253 LLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYK 317
            |||||:||||::.||.|||.|:...:...:||:||.||:|||.....|.|.|..||||||||.||
  Fly   279 LLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYK 343

Human   318 DCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSC 382
            |.:...|:||||||:||||:||:||:|:...||.|.:||..||||.|:.:|.|:..||.|..|:.
  Fly   344 DALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWAL 408

Human   383 LFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYI 447
            :||:||:.|||||.|...|.::||..|.||:..|   .|||.:..:..:.:::||...|:||.|.
  Fly   409 IFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVVGLASCTQGGFYF 470

Human   448 FQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLAT 512
            |.|.|.|| :|..:|....||.:.:||:||.:||.::|.||||:.|....::.|.|:.|...|..
  Fly   471 FHLLDRYA-AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFI 534

Human   513 FLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITP 575
            .::.|..|.||.|.: ||||.|..::||.:|.||:|.:|...:..||.|.|..|:|...|.||
  Fly   535 TVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	261/575 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		264/583 (45%)
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	262/575 (46%)