Protein Alignment SLC6A12 and bdg

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Alignment Length: 671
• Identity: 153/671 - (22%)
• Similarity: 247/671 - (36%)
• Gaps: 155/671 - (23%)

Human    38 QWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQ 102
            ||.:.....|::.|..:|:.|:.||..|.. |.||.|.:.:.:...:.|||:.:|::.||.....
  Fly   496 QWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRA 559

Human   103 GSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF-WNT--- 163
            |.|:.| ||.|:..|:|:|.|:.:.:|.:|..:.|||.|.||...|    |....:.: |..
  Fly   560 GPVSMW-KISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVF----PTAARSGYRWQEMAF 619

Human   164 EHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH-----DLGSLRW-----ELALCLL 218
            .:..|..|.:|        |.|..|.|::...||   ..:|     |...:|:     :||..|.
  Fly   620 PYRYDASNATG--------NLTQTVAEYFNVVVL---QRLHLANHPDASGIRFHVNDRQLAFYLA 673

Human   219 LAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTL--PGAYQGIIYYLKPDLFRLKDP 281
            |.|...:..:.||:||.||:.|...|.|.:.|.::..:.|.:  |...|.|......|.| |.:.
  Fly   674 LIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDF-LVNS 737

Human   282 QVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYK-----DCI----------------ALC-- 323
            ..|..|..:.|.::.:....:.|:.|  :.|.|..|     |.|                |||
  Fly   738 NSWTAATQETFLTWGLLGASVIAITS--RSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCA 800

Human   324 -------FLNSATSFVAGFVVFSILGFMSQEQG---------VP-----ISEV---------AES 358
                   ::....||.......||....|....         :|     |.|.         .||
  Fly   801 QILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVES 865

Human   359 G-PGLAFIA--FPKAVTMM--PLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKS 418
            | ..|.||:  ||..:::.  .:|.:|:.:.|  ..|.|.....:||         |:.......
  Fly   866 GFQALRFISEIFPAVLSLASDSISWVWAAVAF--ATFAGFGLAQLCV---------MWKPISSAL 919

Human   419 GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISW---VYGADR 480
            |.....:|...|...|:.:...||.|:.|....|:       ||..|.|  :.|.|   ::|.
  Fly   920 GNSTSSVLLSCVTGLLLSIPFATEMGISILYYVDF-------LLGGSWF--IPIIWTAQIFGV-- 973

Human   481 FYDNIEDMIGYRPW----------------PLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVY 529
                  .:|..||:                ..:.:||..|.|   :.....|:..|.....|..|
  Fly   974 ------FLIRGRPYNGDDLVNDLRLCGSMSAFLALSWNVLLP---IGLITLSVVDYKASLSNQFY 1029

Human   530 ------VYPPWGYSIGWFLALSSMVCVPLFVVITLLK--TRGP--FRKRLRQLITPDSSLPQPKQ 584
                  .:..|...:|..:.:..::.:|:..:|.:.:  ..||  ..:|::.|..|.....:|::
  Fly  1030 YWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPRR 1094

Human   585 HPCLD-GSAGRNFGPSPTREG 604
            ..... .|..|......|.||
  Fly  1095 PSARQTASQSRRNALGQTTEG 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	146/639 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		6/30 (20%)
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	125/522 (24%)