Protein Alignment SLC6A12 and CG1698

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_610517.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 224/618 - (36%)
• Similarity: 332/618 - (53%)
• Gaps: 60/618 - (9%)

Human     2 DGKVAVQE---CGPPAVSWVPEEGEKLDQEDEDQV-KDRGQWTNKMEFVLSVAGEIIGLGNVWRF 62
            :||..:.|   ..||     |..|:.....:..|. |.|..|.|.:||::|.....:||||||||
  Fly    41 NGKKTLSEGSGSAPP-----PGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRF 100

Human    63 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIES 127
            |:...:||||||.|||.|...:.|.||::||:.|||::|:|||..: ...|:.:|||...|:...
  Fly   101 PFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVY-DFSPIMRGIGYGQVLATG 164

Human   128 YLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTD----------FLNHSGAGTVTPFE 182
            .:..||..::|..|.|...||...|||:.|...|.|| |.|          .|..||..|.:...
  Fly   165 IVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTE-CLDSGPQEASRATSLAGSGVRTTSAEF 228

Human   183 NFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPY 247
            .||:.::    |....|..||   |...|.|||.|.:||::....::|||||:||..||.|.|||
  Fly   229 YFTNIIL----REKASIDDGI---GYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPY 286

Human   248 LMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYH 312
            :::::||:|.:|||||:.|::|:|:|...:|.:||||..|.||:|||.|||.|.:....|||::.
  Fly   287 VVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFG 351

Human   313 NNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQG-VPISEVAESGPGLAFIAFPKAVTMMP- 375
            :|.|:|...:..|::.||.::|.::|.|||.::.|.. ..|:.|...|||||||::|.|:....
  Fly   352 HNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKW 416

Human   376 LSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLV 440
            |.||:|.|||:||..||:.|......|:.|...|.|...     :...:::.||::.|.:||..:
  Fly   417 LPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHL-----KNWTVVVGIAIVGYFLGLLYI 476

Human   441 TEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLT 505
            |.||.::..|.||:..:.:.|: |::||:|.|:|:||..|...::|.|||.:.....:|.|..:|
  Fly   477 TPGGQFLLNLVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVT 540

Human   506 PGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFR---- 566
            |.|.|...:::|..|.||||.: |.|....|..||.|:...:..| ||..|..:: :.|..
  Fly   541 PLLMLTILIYTLVLYEPLKYKD-YTYQSGVYVFGWCLSAFGVGQV-LFWAIPAVR-KQPSHLGLW 602

Human   567 KRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPS 599
            .|:|:...|   ||              |:|||
  Fly   603 ARIRKAFEP---LP--------------NWGPS 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	208/555 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		6/24 (25%)
CG1698	NP_610517.1	SLC6sbd	75..552	CDD:271359	188/491 (38%)