Protein Alignment SLC6A12 and CG15279

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 216/598 - (36%)
• Similarity: 329/598 - (55%)
• Gaps: 56/598 - (9%)

Human    26 DQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVF 90
            |||.....::|..|...:||::|.....:|||||||||:....||||||.|||.|..|:.|.|::
  Fly    40 DQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIY 104

Human    91 FLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWT 155
            :||:.:||::|:|||..: .:||..:|:|.........|:.||..::|....|...||.:.|||:
  Fly   105 YLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWS 168

Human   156 TCNNFWNTEHC----TDFLNHS--GAGTVTPFENFTSPVMEFWERRVLGITSG--------IHD- 205
            ||...|.. ||    .|..|.|  .:....| :|:|   |:....||  |||.        :|:
  Fly   169 TCRAEWGI-HCINSAPDASNWSQLESNDQRP-QNYT---MKSQNDRV--ITSSEWYFVKEVLHEK 226

Human   206 ------LGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264
                  :|...|||.:.|.:||...:|.|.:||||:||..||.|.|||:::.:||:|.|||||:.
  Fly   227 PNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSI 291

Human   265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSAT 329
            .||.|::||...::.||:||..|.||.|:|.::|.|.:....|:||:.:|.::|...:..|::.|
  Fly   292 DGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMT 356

Human   330 SFVAGFVVFSILGFMSQEQGV-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLIFLG 392
            |.:|||.:|.|||.::.|.|. .|..|.:.|.|||||::|.|:.... |.|::|.|||:||..||
  Fly   357 SLLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLG 421

Human   393 LDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASS 457
            :.|......|.|||..|.||    ..|:.:..:| |||:.:.|||..:|.||.|:..|.|::.:|
  Fly   422 IGSNIAMTSCSVTAIRDRFP----NFGQWQCSLL-IAVVSFFIGLMYITPGGQYMLTLVDFFGAS 481

Human   458 GICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTP 522
            .|.|: |.:.|:..|.|:||.||...:||.|:|.:.....::.|..:||.:.....::..:.|.|
  Fly   482 MIALV-LGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQP 545

Human   523 LKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG-PFRKRLRQLITPDSSLPQPKQHP 586
            |.|||: |||.|.|||||.:....::.:|:::::.:::..| ....::|...||.
  Fly   546 LTYNNI-VYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK---------- 599

Human   587 CLDGSAGRNFGPS 599
                   :|:|||
  Fly   600 -------KNWGPS 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	207/563 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		4/24 (17%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	207/562 (37%)