Protein Alignment SLC6A12 and CG13795

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_609138.3
• Gene: CG13795 / 34049
• FlyBaseID: FBgn0031937
• Length: 594
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 134/594 - (22%)
• Similarity: 266/594 - (44%)
• Gaps: 86/594 - (14%)

Human    35 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQY 99
            :||:|....:|:.:..|..:.| :|:...:..:.:.|....:|||::..:..:|:..:...:||:
  Fly    19 NRGKWDKPTDFMFACFGLALKL-DVFVASFWMFFDMGILGILPYFVYMSIYLVPIMVIHSFMGQF 82

Human   100 TSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF--WN 162
            :|.|.::|:| :.|.|:|:|..|..:...:.:||.|..|..|.::.:||...||| :|...  |
  Fly    83 SSSGFISAFR-LSPFFKGMGYVSGFLTISMLIYYSIFAAVPLLFIINSFRPTLPW-SCEGLSSW- 144

Human   163 TEHCTDFLNHSGAGTVTPFENFTSPVMEFWE----RRVLGITSGIHDLG---------------- 207
                     |:|:.|::...|.|..:.:|.|    .::|.:.|.::...
  Fly   145 ---------HNGSATLSSSCNKTLILEDFSEYNRSHQLLHVPSVLYFQNHYDSMQQDAVPDWYKD 200

Human   208 -SLRWELALCLLLAWVICYFCIWKGVKST--GKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIY 269
             .|.|.......:.||:..|..:|..::.  ||::.:......::|::..:|.:.||||..|:..
  Fly   201 YELSWHFVGLFAIIWVVIAFIFYKFSETAKFGKLIRYMVIVTLVLLLVCFVRFLFLPGALNGLHR 265

Human   270 YLKPDLFRLKDPQVWMDAGT-----QIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNS-A 328
            |:.|   :..|    |..|.     .:..:|....|.:..|.|:|.:..    |.::..::.| .
  Fly   266 YVTP---KASD----MAMGVVSTFIMVLHAFGAGWGSVITLSSFNGFKT----DIMSYSWIISFG 319

Human   329 TSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLA----FIAFPKAVTMMPLSQLWSCLFFIMLI 389
            ..|:  :::|.::.||.:.....:|:|.::|..|:    :::...|::.|....||:.:::.||:
  Fly   320 QIFI--YIMFGMVSFMLEHYFNELSDVDDNGHVLSHWLLYLSSASALSTMAWPNLWTFIYYSMLL 382

Human   390 FLGLDSQFVCVECLVTASIDMFPRQLRKSGRREL---LILTIAVMCYLIGLFLVTEGGMYIFQLF 451
            ...|......:..::.:..|.|  ::.:..::|:   ||..||    |...:..|..|:..|...
  Fly   383 IAALIVMTTQIFTVLQSLFDEF--EVLRVRKQEVTFGLIGGIA----LCSFYFCTNHGIIFFSAL 441

Human   452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWL-FLTP---GLC-LA 511
            ...|.....||.|.|..||.  |:||.:||..:||.|:| :|:...|:..| |:.|   .:| ||
  Fly   442 GLDAIFSHSLLHLLLLLVVL--WIYGRERFQRDIEFMLG-QPFASWKVFILRFIAPIILVICLLA 503

Human   512 TFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPD 576
            ....|:|:::   |:...|     :.:...|.:..::.:|.:....|.::.|.|.:|.::...|.
  Fly   504 GIALSISEHS---YSTTVV-----FVMSIVLVVLPILAIPGYGFYYLYQSTGTFCERFKRTCRPT 560

Human   577 SSLPQPKQH 585
            ...|...:|
  Fly   561 DWYPVEMEH 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	131/582 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		2/10 (20%)
CG13795	NP_609138.3	SLC5-6-like_sbd	27..505	CDD:271356	118/512 (23%)