Protein Alignment SLC6A12 and CG13793

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_609136.2
• Gene: CG13793 / 34047
• FlyBaseID: FBgn0031935
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 122/534 - (22%)
• Similarity: 227/534 - (42%)
• Gaps: 84/534 - (15%)

Human    35 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQY 99
            :||.|....:::.:..|..:.| :::...:..:.|.|....:||.::..:..:|:..:...:||:
  Fly    11 NRGNWEKPTDYIFACFGLALKL-DIFVASFWFFFNTGIFGMVPYLMYMVIYLVPIMVIHSYMGQF 74

Human   100 TSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF---- 160
            :|.|.::|:| :.|||:|:|..|:.:...|.:||.|..|..|.::.:||...||| :|..|
  Fly    75 SSSGFISAFR-LSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCEGFKSWQ 137

Human   161 ------WN-------------TEHCTDF-LNHSGAGTV----TPFENFTSPVMEFWERRVLGITS 201
                  |:             ||:.|.| :.:....:|    :.||:|.:             .|
  Fly   138 NDTIAKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQN-------------DS 189

Human   202 GIHDLGSLRWELALCLLLAWVICYFCIWKGVKST--GKVVYFTATFPYLMLVILLIRGVTLPGAY 264
            .::|. .:.|.|:....|.|....|..:|..:..  ||.:.:.......:|::..:|.:.||||:
  Fly   190 ELNDY-EISWHLSGLFALVWATIAFIFYKFSEPAKFGKCIRYMVIGTVALLLVCFVRFLFLPGAH 253

Human   265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFF-----SFAICQGCLTALGSYNKYHNNCYKDCIALCF 324
            .|:..|:.|.:....       .||...|     :|....|.:..|.|:|.:..|.......:.|
  Fly   254 LGLKNYMTPSIEEFV-------VGTSSTFIMALQAFGAGWGSVITLSSFNGFKTNIMSYSWIISF 311

Human   325 LNSATSFVAGFVVFSILGFMSQEQGV----PISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFF 385
               ...|:  :::|.::.||.:...:    |:.|.......:.|::...|::.:....||:.:::
  Fly   312 ---GQIFI--YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWTFIYY 371

Human   386 IMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQL 450
            .||:...|......:..::.:..|.| .||| :.::|:.:..|..:. :..|:..|..|:..|.:
  Fly   372 TMLLMAALIVITTQIFTILQSLFDEF-EQLR-AKKQEVTLGLIGGLA-VCSLYFCTNHGVLYFAI 433

Human   451 FDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIG--YRPW---------PLVKISWLFL 504
            ....|.....||.|.|..||.  ||||.|||..:|:.|:|  :..|         |...:..|.|
  Fly   434 LSIDAIFSQTLLHLLLLLVVL--WVYGRDRFQKDIKFMLGQPFASWKVFILRFVAPPTLVICLVL 496

Human   505 TPGLCLATFLFSLS 518
            ...:||....:|.|
  Fly   497 EIKMCLEEHSYSSS 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	122/534 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	115/512 (22%)