Protein Alignment SLC6A12 and ine

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_477012.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 240/570 - (42%)
• Similarity: 364/570 - (63%)
• Gaps: 9/570 - (1%)

Human    12 PPAVSWVPEEGEKLDQEDED-QVKDRGQ-WTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAF 74
            ||.:. |.::...||..||. |:|.|.| |.|||:|||:..|..:||||||||||:|||:|||.|
  Fly   312 PPPLG-VDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVF 375

Human    75 FIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAW 139
            .:||.|..|:|.||:.|:|:::||||.:|.:.|..::||||:|.||||||:...::.||.:|:.:
  Fly   376 LVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGY 440

Human   140 ALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH 204
            :::|.|:||.:|:||..|||.|||..|. .....|.....| :...:|..||:|.:||.|:.|:.
  Fly   441 SIYYFFTSFKTEMPWIDCNNRWNTPDCW-VPQRKGINASAP-DTSRTPSEEFFENKVLQISGGLE 503

Human   205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIY 269
            ..|.:||||..||:.||::.||..||.:||:.||.|||||||:::::||::|.|||.||.:|:.:
  Fly   504 YPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRF 568

Human   270 YLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAG 334
            :.:|....||:..||::|.:|.|.|..|..|.:.:..|||||:||..:|.:|:..:|..||.:.|
  Fly   569 FFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVG 633

Human   335 FVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399
            ...||.||.::.||...:.:|...|||:.|:.:|:|:..||.:|||:.:||.||:.|||:|||..
  Fly   634 IFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAI 698

Human   400 VECLVTASIDMFPRQLRKS-GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLF 463
            ||.:||:..|.|||.:::. |..|:::|.:.|:..|.|:..:.:||:|.|||.|:||:| :.::|
  Fly   699 VEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMF 762

Human   464 LSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKY-TPLKYNN 527
            |:..:::.|:|.||..|...|::.|.|..|...::..||.|.|.|..|.::.||..| .|..:|.
  Fly   763 LAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNG 827

Human   528 VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG-PFRKRLRQLITPD 576
            .|.||.|.|.|||..|..|::|:|.:.||..|::.| .|.:|:|..:.|:
  Fly   828 RYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPN 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	230/543 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		0/1 (0%)
ine	NP_477012.1	SLC5-6-like_sbd	337..876	CDD:444915	229/541 (42%)