Protein Alignment SLC6A12 and NAAT1

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 210/582 - (36%)
• Similarity: 313/582 - (53%)
• Gaps: 46/582 - (7%)

Human    23 EKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGI 87
            ||.|.  |....:|..|.|.:||::|.....:|||||||||:..|:||||||.|||.|..|:.|.
  Fly    27 EKTDA--EKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGK 89

Human    88 PVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSEL 152
            |:::||:.:||:||||:|..| .:.|.|.|:|.........:..||..:||..|:|||.||.|||
  Fly    90 PMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSEL 153

Human   153 PWTTCNNFWNT-------EHCTDFL------NHSG---AGTVTPFEN----------FTSPVMEF 191
            ||:.|.:.|..       |:..:.|      |.|.   :|.|...|.          |.:.|:
  Fly   154 PWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVI-- 216

Human   192 WERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIR 256
              :..|.|:.|:   |...|:|.|.|.:|||:.:..|.:||||:||..||.|.|||::|.:||||
  Fly   217 --KEKLDISDGV---GDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIR 276

Human   257 GVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIA 321
            .|||.||..||:::|:|....|.:|.||.:|..|.|||.|:..|.:....|||::.:..|:|.:.
  Fly   277 AVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMI 341

Human   322 LCFLNSATSFVAGFVVFSILGFMSQEQGVP-ISEVAESGPGLAFIAFPKAVT-MMPLSQLWSCLF 384
            :..|::.||.:.|..:|:|||.::....:. |.:|..||.|||||::|.|:: ...:.||:|.||
  Fly   342 VTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLF 406

Human   385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQ 449
            |.||..||:.|.......:||...|.|     |..:...:.||.:|..:|:||..||.||.:|..
  Fly   407 FFMLFVLGIGSIVALQSTIVTIICDQF-----KGWKYWKVALTTSVCGFLMGLVYVTPGGQWILT 466

Human   450 LFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514
            |.|:|..:.: :..|::||:..|.||||...|.|:||.|...|.....::.|.|.||.:.:..|:
  Fly   467 LVDFYGGTYV-VFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFI 530

Human   515 FSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLK-TRGPFRKRLRQLITP 575
            :|:....|:||:.:| :|......||.|........||:.:..:.: .:|.:.|.|:..:.|
  Fly   531 YSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKP 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	205/568 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		210/582 (36%)
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	190/506 (38%)