Protein Alignment SLC6A12 and CG33296

DIOPT Version :10

• Sequence 1: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 603
• Identity: 129/603 - (21%)
• Similarity: 255/603 - (42%)
• Gaps: 115/603 - (19%)

Human    36 RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYT 100
            ||:|....:::.:..|..:.| :::...|..:.|.|....:|||::..:..:|:..:...:||::
  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83

Human   101 SQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF--WNT 163
            |.|.:.|:| :.|||:|:|..|:.:.....:||.:.:|..|.:|.:||...||| :|...  |:.
  Fly    84 SSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWHN 146

Human   164 E--------HCTDFLNHSGAGTVTPFENFT----SPVMEFWE---------RRVLGITSGIHDLG 207
            .        |.|.:..|         ||:|    :|...:::         .:...|:..:..|.
  Fly   147 RTDEYPTLCHPTIYKQH---------ENYTLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLF 202

Human   208 SLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLK 272
            :|.|     .|:|.:..:|   ......||.:.:......:::|:..:|.:.|||:::.:..|:.
  Fly   203 TLSW-----ALIAIIFYHF---SEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYIT 259

Human   273 PDLFRLKDPQVWMDAGTQIFFSFAIC-------QGCLTALGSYNKYHNNCYKDCIALCFLNS-AT 329
            |:.         .|....|:.:|.:.       .|.:.||.|:|.:..    |.::..::.| ..
  Fly   260 PNT---------KDFSEGIYSTFIMALQAFGAGWGSVIALSSFNGFKT----DIMSYSWIISFGQ 311

Human   330 SFVAGFVVFSILGFMSQEQGVPISEVAE----SGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIF 390
            .|:  :::|.::.||.::....||:...    ....:.|::...|:..:....||:.:::.||:
  Fly   312 IFI--YIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLL- 373

Human   391 LGLDSQFVCVECLVTASIDMFPR-QLRKSGRRELLILTIAVMCYL--IGLFLVTEGGMYIFQLFD 452
              |.|..|....|.|....:|.. :..|..::|   :|..::|.|  ...|..||.|.:
  Fly   374 --LASLTVIATQLFTVLQSLFDEFEKLKERKQE---VTFGIICGLAICSFFFCTEHGSF------ 427

Human   453 YYASSGICLL----FLSLFEVVCISWVYGADRFYDNIEDMIG--YRPW---------PLVKISWL 502
            |:|..||.::    .|.|..::.:.|:||..||..:||.|:|  :..|         |:|.:..:
  Fly   428 YFAILGIDVILAHSLLHLLLLLVVLWIYGQKRFQRDIEFMLGQPFASWKVFILRYTAPIVFLICM 492

Human   503 FLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRK 567
            .|....|:....|         :..|::.      :|..|.:...:.:|.:....|.::.|.|.:
  Fly   493 ILGIIECIRVHFF---------FKEVFLV------LGIILVVLPFLAIPGYGFYYLRQSPGTFLE 542

Human   568 RLRQLITPDSSLPQPKQH 585
            ||::...|....|...:|
  Fly   543 RLKRSCRPTDWYPVEMKH 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	126/591 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		2/10 (20%)
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	112/515 (22%)