Protein Alignment SLC6A11 and GlyT

DIOPT Version :9

• Sequence 1: NP_055044.1
• Gene: SLC6A11 / 6538
• HGNCID: 11044
• Length: 632
• Species: Homo sapiens
• Sequence 2: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 253/616 - (41%)
• Similarity: 364/616 - (59%)
• Gaps: 60/616 - (9%)

Human    27 GCSSG-----------GAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLC 80
            ||:||           ||..|       .::.||||.|..:.:|:||:.|..:||||||||||||
  Fly    30 GCASGTALIQLDATGPGAGGA-------GESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLC 87

Human    81 YKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNV 145
            |.|||||||||:.:..:..|:|:.|:|.:.||:.:.|.:..:|:.||||.|:|....::.|.:.:
  Fly    88 YNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVML 152

Human   146 YYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNV-----SNYSHVSLQNATS---- 201
            ||.:|:||.|||:...|...|||..|...|:|:.|..:.:.:.     ..|...:..||||
  Fly   153 YYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAEN 217

Human   202 -------------PVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKV 253
                         |..|::.:.||.:|.|||..|:::..||.||..||||.:.|:.||.:|:|||
  Fly   218 NITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKV 282

Human   254 VYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLT 318
            ||.||.|||::|:||.:|||||||||.||.|||.||..:|::.|||.||..||||:.:...|.|.
  Fly   283 VYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLI 347

Human   319 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYP 383
            .|.|||.::||||:|.:::...|..|||.||..|||::||:|:|..|.:.:|.:.|.|||||.||
  Fly   348 TLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYP 412

Human   384 KAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISY 448
            :.||.:|:||:||.|||:||:.|||||||..:|::.||::|.:|.:  |.| :..::|::::..|
  Fly   413 EVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNL--RQY-KIWVVLSVAIFGY 474

Human   449 FLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIK 513
            ..||...|..|||..||.|.|||:...|| :||.|||.|.|:|||.||.::|:.|||.|     .
  Fly   475 IGGLGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKR-----S 533

Human   514 W--------CWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWIC 570
            |        .|..:||.....|..|..::|||.||.: |.||.|...:||::.|..:|.|.|...
  Fly   534 WFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH-YVYPMWADAVGWIVGLLPVLVIFLVAF 597

Human   571 ITVWKTEGTLP--EKLQKLTTPSTDLKMRGK 599
            ..:|:...:|.  ::::.|..|:.:....|:
  Fly   598 QEIWRAPMSLSFRDRIKHLLQPTAEWGPAGR 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		7/24 (29%)
		SLC6sbd_GAT3	49..590	CDD:212077	243/572 (42%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	240/555 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820