DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A11 and ine

DIOPT Version :9

Sequence 1:	NP_055044.1	Gene:	SLC6A11 / 6538	HGNCID:	11044	Length:	632	Species:	Homo sapiens
Sequence 2:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	229/546 - (41%)
Similarity:	345/546 - (63%)	Gaps:	13/546 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    52 HWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSE 116
            ||.||::|||:..|..:||||||||||:|||:|||.||:||.:....|.||:.|:|.::||:|..
  Fly   339 HWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGR 403

Human   117 GGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCV 181
            |.|....::||||:|.|.|:.|:...::.||.:|:.::|:|....|.||:||..|.:.|||.:|.
  Fly   404 GPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCW 468

Human   182 EFQK--LNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIW 244
            ..|:  :|.|     :...:.:|..||:|::||.||.|:|:.|.:||||..||:.||.:.||..|
  Fly   469 VPQRKGINAS-----APDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATW 528

Human   245 KGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFS 309
            |..||:.||.|.|||||:::::||::|.|||.||:||::|:..|..|.|.:..||::|.:|.|.|
  Fly   529 KSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNS 593

Human   310 YAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESG 374
            ..|..|.:.:..|||.||||..||.:.:..:|..||.:.|...||.||.:|.||...:.:|...|
  Fly   594 LGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDG 658

Human   375 PGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRR--GYRRE 437
            ||:.|:.||:|:..||.:.|||.:||.||:.|||:|||..||.:||::.|.:|:..:|  || .|
  Fly   659 PGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY-HE 722

Human   438 LLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIED 502
            :::|.:.|||...|:..:.:||:|.|||.|.|||| :.::|:|..:.|.|.|.||:.|...|::.
  Fly   723 IVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYGTGRLSKNVKQ 786

Human   503 MIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKY-KPLKYNNIYTYPAWGYGIGWLMALSSMLCIP 566
            |.|..|...::.||:::.|.:...|::..||.| :|..:|..||||.|.|||||:.|..|::|||
  Fly   787 MTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIP 851

Human   567 LWICITVWKTEG-TLPEKLQKLTTPS 591
            .:..|...::.| |..|:::....|:
  Fly   852 GYAVINFLRSSGDTFWERIRNTLRPN 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
SLC6A11	NP_055044.1	SLC6sbd_GAT3	49..590	CDD:212077	228/543 (42%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	228/543 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820