Protein Alignment SLC6A9 and GlyT

DIOPT Version :9

• Sequence 1: NP_964012.2
• Gene: SLC6A9 / 6536
• HGNCID: 11056
• Length: 706
• Species: Homo sapiens
• Sequence 2: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 295/628 - (46%)
• Similarity: 411/628 - (65%)
• Gaps: 44/628 - (7%)

Human    49 PSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTS 113
            |||:::        |..:...|.||.|   ......||..||.       :||.|..:.:|:|:.
  Fly    24 PSTAIS--------GCASGTALIQLDA---TGPGAGGAGESEH-------ERGTWTGRFDFLLSL 70

Human   114 VGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPM 177
            :||:||||||||||||||.||||||:.|:.|||:..|:||.||||||||:|:.|.:.|: |..|:
  Fly    71 LGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPL 135

Human   178 FKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGV--LDASNLTN 240
            |:|:|.||::||..:.:|||::|....:|.|:|...||||..|...|:|..|...  .|....||
  Fly   136 FRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATN 200

Human   241 G--------SRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVS 297
            |        :..:|..:|::.|...:|:| .|:|||:..:||.||..|...|.::|.|..||.::
  Fly   201 GTYYLRTCHNATSAAENNITTLALGALKR-PPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLA 264

Human   298 WLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWG 362
            |.:|||||.:||:||||||||||.||||||.|||||||||.||..||::||||.|.::..|:|||
  Fly   265 WTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWG 329

Human   363 DAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGV 427
            |||.|||::|..|||||||::|||||.||||:||:|::..|.|||.:||.|||||:||:|:.|.|
  Fly   330 DAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNV 394

Human   428 DVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 492
            ||.:|.|.|.||||:.|||.:|.||:||:|::|||.||:.|||.:||.|:||:.|||:|...|
  Fly   395 DVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPN-- 457

Human   493 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYF 557
            :.|.|.:|.|.||:.|::.|:..|:.:|:|||.|||.|||::|:::|:...|:.|.:|||.:.:.
  Fly   458 LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFL 522

Human   558 QDIQMMLG-------FPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFL 615
            .|||.|:|       |    |:.|.||:::||.:.|||.|..::|:|..|.||.||.||.|:|::
  Fly   523 NDIQGMIGKRSWFWNF----FWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYPMWADAVGWI 583

Human   616 MALSSVLCIPLYAMFRLCRTDGD-TLLQRLKNATKPSRDWGPA 657
            :.|..||.|.|.|...:.|.... :...|:|:..:|:.:||||
  Fly   584 VGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPA 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A9	NP_964012.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		SLC6sbd_GlyT1	84..667	CDD:212067	287/593 (48%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	275/552 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	571	1.000	Domainoid score	I225
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3948
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10344
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.900