DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A8 and GlyT

DIOPT Version :9

Sequence 1:	NP_005620.1	Gene:	SLC6A8 / 6535	HGNCID:	11055	Length:	635	Species:	Homo sapiens
Sequence 2:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	675	Identity:	279/675 - (41%)
Similarity:	392/675 - (58%)	Gaps:	67/675 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     2 AKKSAENGIYSVSGDEKKGPLIAPGP--DGAPAKGDGPV-----GLGTPGGRLAVPPRETWTRQM 59
            :.||...|:..|.|.   |.::.|..  .|. |.|...:     |.|..|...:...|.|||.:.
  Fly     4 SSKSGSAGVGGVGGG---GGVVCPSTAISGC-ASGTALIQLDATGPGAGGAGESEHERGTWTGRF 64

Human    60 DFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVW 124
            ||::|.:|::||||||||||||||.||||.||||:.::.::.|:|:.|:|:|.||:...|.:.|:
  Fly    65 DFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVY 129

Human   125 -NICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHE 188
             ..||||:|||...:::......||.:::||..:|:..||...|||..|...|:|..|....:.:
  Fly   130 RRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQAD 194

Human   189 DCA------------NASLA---NLTCDQL-ADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTL 237
            .|.            ||:.|   |:|...| |.:|.|..|::.|.||.||.|:|..|::...:..
  Fly   195 QCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAA 259

Human   238 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGS 302
            ||...|.:|:.|:.|||:|:||:|||||.|||||||:|.||||.||||..||::||.|||.:|.:
  Fly   260 CLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLAN 324

Human   303 PQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMA 367
            .|||.||..||||:.:...|.|..|.|||:|:||||||::|:|..|..||||||.|:|||:||:|
  Fly   325 AQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLA 389

Human   368 AEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDL 432
            .|..|.:.||.:.|.|||||.||..||.:||:|:||.|||.|||.|||||||..:|...|.:||.
  Fly   390 HELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDR 454

Human   433 LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 497
            .|....::....:|||:   ..::..|...|:.|||..||.|.|:|:.:.|| .|..||:::||:
  Fly   455 FPNLRQYKIWVVLSVAI---FGYIGGLGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWI 515

Human   498 YGADRFMDDIACMIGYRPCPWMKWCWSFF--------TPLVCMGIFIFNVVYYEPLVYNNTYVYP 554
            ||:.||::||..|||.|     .|.|:||        ||...:.|..||.|.|:|..|.: ||||
  Fly   516 YGSQRFLNDIQGMIGKR-----SWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH-YVYP 574

Human   555 WWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMA--ERWQHLTQPI--WG--------LHHLEYR 607
            .|.:|:||...|..:|.:.|.....:.||..:::  :|.:||.||.  ||        ||...|:
  Fly   575 MWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPAGRPCVNLHAERYQ 639

Human   608 AQDADVRGLTTLTPVSESSKVVVVE 632
            :|:.|  |:|       ::|:::.|
  Fly   640 SQNYD--GVT-------NTKILIEE 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		7/27 (26%)
SLC6A8	NP_005620.1	SLC6sbd_CT1	52..621	CDD:271397	264/605 (44%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	248/555 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820