Protein Alignment SLC6A6 and CG8850

DIOPT Version :10

• Sequence 1: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 210/616 - (34%)
• Similarity: 319/616 - (51%)
• Gaps: 65/616 - (10%)

Human    71 RHSRAERGRRRSHPRSRTRTTALLRSSQTKEMATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEA 135
            |:.:..:|.|..||.|....:.::.|::.:|:.    :.|                   ..|.|:
  Fly    12 RNMQGAQGSREGHPGSNDGISTVIYSAEGEELT----INC-------------------EAESES 53

Human   136 EGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 200
            .|   ||::||..::|:.|.....||||||||||::..:||||||||||.|.|...|.||::||:
  Fly    54 SG---QRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPYVIVLLLIGRPVYYLEV 115

Human   201 IIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNH 265
            ||||::|.|.|..:: :.|:..||.|..|...:|...||..|:|....||..||.:.|||.:|..
  Fly   116 IIGQFSSRGCIRAFD-MAPIMRGIAYGQVYSTALATTYYACIMALTIRYLVASFSEVLPWTYCLV 179

Human   266 SWNTPHCMED--TMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHP--GSLKWDLALCLL 326
            .|. ..|:..  |...:.|:...:||...      |:.:.||.....:|..  |:..|||.||||
  Fly   180 EWG-KSCVATGATAANDSSIVQGVSSAEL------FFTQTVLREPESLDDNGLGTPSWDLVLCLL 237

Human   327 LVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQV 391
            ..|::....:.||:||:||..||.|.||:.:::|||:|.:|||||..||.::|.|..::|.:|.|
  Fly   238 ATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHV 302

Human   392 WIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQ 456
            |..|.||:|||.|||.|.:....|:|.:..|.::|.:::..::|.||.::|..||.|||.:|.|.
  Fly   303 WYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFET 367

Human   457 GV-DIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLY 519
            .. ||:.|.:.|.|||||:||:|:.... ||..:::|||.|||:||:.|........:..:.|.:
  Fly   368 NTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF 432

Human   520 ---PSFLRKGYRREIFIAFVCS-ISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVI 580
               |.:|         :|...| |.:|.||..:|.||.:|..|.|:|..:.:.|: :|..|...:
  Fly   433 THLPHWL---------LAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIALV-LAIAELLAV 487

Human   581 AWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYN-----KTYVYP 640
            .||||...:...||.|:..:...:.:..||::.|.|.....::.|..|.||||.     ..|...
  Fly   488 GWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMA 552

Human   641 NWAIGLGWSLALSSMLCVPLVIVIRLCQTEG 671
            .|.|   |.|   .:|.:|...::.:.|..|
  Fly   553 GWII---WGL---GVLQLPFWALVTIYQQPG 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	197/545 (36%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	181/491 (37%)