DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A6 and ine

DIOPT Version :9

Sequence 1:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens
Sequence 2:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	247/607 - (40%)
Similarity:	364/607 - (59%)	Gaps:	40/607 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   133 DEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFF 197
            ||.....|:::.|::|:.|||:..|..|||||||||||:|||:|||.||:||.|.||...:|:.|
  Fly   328 DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLF 392

Human   198 LEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAH 262
            :|:.:||||..|.|....::||||.|.|.||||:..|::.||.||:.::.||.|.||:.|:||..
  Fly   393 MELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWID 457

Human   263 CNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLL 327
            ||:.||||.|.   :.:.|.:..:...|:.| |..||:|..||.:|.|:::||.::|:|..||:.
  Fly   458 CNNRWNTPDCW---VPQRKGINASAPDTSRT-PSEEFFENKVLQISGGLEYPGMMRWELFACLIC 518

Human   328 VWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVW 392
            .||:.:|..||.::|:.||.||||||||.::::|:||.:||.||..|::|:..|..:.|::..||
  Fly   519 AWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVW 583

Human   393 IDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQG 457
            |:|.:|.|.|..|..|:|.|..|||||..|..||.:.:..:|..||.:.|...||.||.:|.||.
  Fly   584 INAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQN 648

Human   458 VDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSF 522
            .::.||...|||:.|:.||:|:..||....|:::||.|||.|||:|||..||..:||:.|.:|.:
  Fly   649 TNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRW 713

Human   523 LRK--GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 585
            :::  || .||.:.|||.||.|.|:..:.:||:|.|||.|:|||| |.::::||.:...|||.||
  Fly   714 IKRHLGY-HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAAS-VTIMFLAFCQMIAIAWFYG 776

Human   586 GDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTY-NKTYVYPNWAIGLGWS 649
            ...|...::.|.|..|..:::..|.|:.|.|....::.||:.|...|| |..|.||:||.|:||.
  Fly   777 TGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWM 841

Human   650 LALSSMLCVPLVIVIRLCQTEG-PFLVRVKYLLTPR-----------------EPNRWAVEREGA 696
            .|..|::|:|...||...::.| .|..|::..|.|.                 |..::.:.:|.|
  Fly   842 FASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMA 906

Human   697 TPYNSRTVMNGALVKPT--HII 716
            |.|           |||  |::
  Fly   907 TVY-----------KPTNPHLL 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	234/544 (43%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	234/544 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820