Protein Alignment SLC6A6 and snf-11

DIOPT Version :10

• Sequence 1: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Sequence 2: NP_505873.2
• Gene: snf-11 / 191770
• WormBaseID: WBGene00004910
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 594
• Identity: 288/594 - (48%)
• Similarity: 389/594 - (65%)
• Gaps: 47/594 - (7%)

Human   141 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQY 205
            :||:|||..||::|..|..:|||||||||||||:||||||||||.|.|...|.|:|.||...||.
 Worm     9 EREQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYCISLVFCGAPLFILETSWGQL 73

Human   206 TSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSF-QKELPWAHCNHSWNT 269
            .|.||:..: ||||:|.|:|.|:.|:...||:||||:|:||..||:.|| ..::||.:|:|:|||
 Worm    74 MSVGGLGMF-KICPIFKGVGIAAAVMAFWLNIYYIVVLSWAATYLYNSFTMSDVPWKNCDHAWNT 137

Human   270 PHCMEDTMR----KNKSV----------------------------WITISSTNFT--SPVIEFW 300
            |:|..:.::    .|:::                            |...|:.:.:  |||.|||
 Worm   138 PNCRSEYVKIPCDSNRTIAEFFNVKVLTHDHIHEYKKQFFVGEKMNWTVCSAADLSVVSPVKEFW 202

Human   301 ERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRG 365
            ...||.:|.|:::||.::|||||.|||||::|:.||:|||:.||||||.||:||:.||..||:||
 Worm   203 NHRVLGISSGLENPGGIRWDLALFLLLVWIICYLCIFKGVKWTGKVVYITASFPYMMLFCLLIRG 267

Human   366 LTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLL 430
            |||.|||.|::|||.||.::|.:.:||:||.||:||||.:.|||:.:||||||:..|.|:..:.:
 Worm   268 LTLEGAGVGLEFYLKPDFSKLLESKVWVDAVTQVFFSYGLGLGALVALGSYNKFNNNVYKQALTV 332

Human   431 GCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIM 495
            ..:|||||..:||.|||.:||||.:|...:|:||::||||.|:|||..:..:|...|||.|||:|
 Worm   333 CFVNSGTSVFAGFVIFSFIGFMATQQEKSVAEVAQAGPGLLFLAYPSGILQLPYTQFWSCLFFLM 397

Human   496 LLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFD 560
            :|.||:||||..:||..|:::|.:|...||.|.||||:..:|.||||:|||.|||||.|||||||
 Worm   398 VLFLGVDSQFCTMEGFFTAIIDEFPQIRRKKYGREIFVGVICVISYLIGLTTVTEGGFYVFQLFD 462

Human   561 YYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSL 625
            :|||||..|||:.||||..|:|..|.|..|:.::.||||.|..|.|:.|...||.:|.|..:|.|
 Worm   463 FYAASGWALLWLLFFECIAISWSLGIDRWYEHMKSMIGYYPSAWWKFCWVFATPSVCFGVLLFGL 527

Human   626 VKYVPL---TYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPN 687
            :||.||   .||  |.||.|....||.|:||||||:|...:....:|.|....::|.|..|
 Worm   528 IKYQPLRIDAYN--YDYPVWGHIFGWFLSLSSMLCIPGYAIWIWFKTPGTVQEKIKLLCRP---- 586

Human   688 RWAVEREGA 696
              .:|.:||
 Worm   587 --DIEIKGA 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	284/578 (49%)
snf-11	NP_505873.2	SLC6sbd-TauT-like	10..586	CDD:271387	284/578 (49%)