DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POTEI and act-5

DIOPT Version :9

Sequence 1:	NP_001358855.1	Gene:	POTEI / 653269	HGNCID:	37093	Length:	1097	Species:	Homo sapiens
Sequence 2:	NP_499809.1	Gene:	act-5 / 176793	WormBaseID:	WBGene00000067	Length:	375	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	320/375 - (85%)
Similarity:	347/375 - (92%)	Gaps:	0/375 - (0%)

- Green bases have known domain annotations that are detailed below.

Human   723 MDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGIL 787
            |:::.|.||:|||||||||||||||||||||||||||||.||:|.||.||:||||.|||||||||
Worm     1 MEEEIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGIL 65

Human   788 TLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTP 852
            |||||:||||:|||||||||||||||||||:||||||:||||||||||:||||||||||||||||
Worm    66 TLKYPIEHGIVTNWDDMEKIWHHTFYNELRIAPEEHPVLLTEAPLNPKSNREKMTQIMFETFNTP 130

Human   853 AMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTE 917
            ||||.|||:||||.||||||||:|:|||||||||||:|.|||||..|||||||:||||:||||||
Worm   131 AMYVNIQAVLSLYASGRTTGIVLDTGDGVTHTVPIYEGYALPHAIQRLDLAGRDLTDYMMKILTE 195

Human   918 RGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEA 982
            |||.|||.|||||||||||||||||.|||.|:|.||||||||||||||||||||||||.|||||.
Worm   196 RGYTFTTTAEREIVRDIKEKLCYVAHDFESELAAAASSSSLEKSYELPDGQVITIGNERFRCPEV 260

Human   983 LFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSML 1047
            ||||.|:|||..||||||:.||||.|||||||||.||||||||:|:||:|.||||||..||||.:
Worm   261 LFQPAFIGMEGAGIHETTYQSIMKCDVDIRKDLYANTVLSGGTSMFPGIADRMQKEIQHLAPSTM 325

Human  1048 KIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF 1097
            ||:|||||:||||||:||||||||||||||||||||||||||||||||||
Worm   326 KIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POTEI	NP_001358855.1	Ank_2	158..>361	CDD:393464
		ANK repeat	174..203	CDD:293786
		ANK repeat	205..236	CDD:293786
		ANK repeat	238..269	CDD:293786
		ANK repeat	271..302	CDD:293786
		ANK repeat	304..335	CDD:293786
		CCDC144C	670..>723	CDD:373382	320/375 (85%)
		NBD_sugar-kinase_HSP70_actin	723..1097	CDD:388382	318/373 (85%)
act-5	NP_499809.1	NBD_sugar-kinase_HSP70_actin	1..375	CDD:302596	318/373 (85%)
act-5	NP_499809.1	ACTIN	6..375	CDD:214592	317/368 (86%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H135259
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D283838at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100127
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720