DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A4 and List

DIOPT Version :9

Sequence 1:	NP_001036.1	Gene:	SLC6A4 / 6532	HGNCID:	11050	Length:	630	Species:	Homo sapiens
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	193/551 - (35%)
Similarity:	303/551 - (54%)	Gaps:	36/551 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    80 ETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHR 144
            |.||..::||.|.|..:|.|||:||||||.:|||||.|::||.|..:..|.|::|:|::|||:..
  Fly    19 EQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTG 83

Human   145 NGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNT--- 206
            .|.:..: .:.|:.||:.....:......:||::|||..|.:.::||..:|||:.|..||.|
  Fly    84 RGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGTDCH 147

Human   207 -GNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS---WQLALCIMLIFTVIY 267
             ||..|         :....|||:.::.|.:|  |....:.:  |:|   |||..|:.:.:.||.
  Fly   148 DGNAQN---------SSGKMSPAQLYFEREIL--HEVPNIDN--GLSLPNWQLVACLAIAWLVIG 199

Human   268 FSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQ 332
            ..:.:|:|:|||..:....|||::|.:||:|..|||||..|::::.||.|::||...||..|..|
  Fly   200 GVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQ 264

Human   333 IFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSE 396
            :||||...||.|:.:||||.||.|.|.|.::.:.::..:|.::|.:.|.:||.:| |..|.|:..
  Fly   265 VFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGS 329

Human   397 VAKDAGPSLLFITYAEAIANMP-ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEF----PH 456
            |.| .|..|.||:|.||||... ....||::|||||..||:.||......::..:.|:|    |.
  Fly   330 VVK-GGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPP 393

Human   457 VWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQF 521
            :|     :....:.:..|..|:|.:|.||.:::.|::.|......|.:|:.|.|||:|.||:.:|
  Fly   394 IW-----KLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRF 453

Human   522 CRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSF 586
            |.|:|.|:|...||:||:||..|:|..:..::...|:....|......||..:.:.|..:.|...
  Fly   454 CEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGL 518

Human   587 ICIP---TYIAYRLIITPGTFKERIIKSITP 614
            |.:|   .|..|:.....|:|.:||..:..|
  Fly   519 IQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		5HT_transport_N	24..64	CDD:397524
		SLC6sbd_SERT	79..615	CDD:271399	193/551 (35%)
		Interaction with RAB4A	616..624
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	178/489 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920