Protein Alignment SLC6A4 and CG13796

DIOPT Version :10

• Sequence 1: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_609140.2
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 658
• Identity: 167/658 - (25%)
• Similarity: 275/658 - (41%)
• Gaps: 107/658 - (16%)

Human     6 LNSQKQLSACEDGEDCQENGVLQKVVPTPGD------KVESGQISNGYSAVPSPGAGDDTRHSIP 64
            ||:...|..||:.|...|         .|||      :.|||....|..|:.:........||:.
  Fly     9 LNNCMLLGDCENSEHGTE---------LPGDFIGEPVETESGGGMGGSLALAARRIRSRQVHSMA 64

Human    65 ATTTTLVAEL-----HQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQ--------NGGG- 115
            ..|.:....|     |...|..|.|..||..:...:|        |..:.:.        :||.
  Fly    65 VRTGSAYDTLERPYRHDKCRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGGWL 121

Human   116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180
            .|::.|.:..:|..:|:|.::..|||:..:|.||.:| :.||||||||||.::.....:||:...
  Fly   122 LFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFR-VAPIFKGIGYAILLLNLGTLTYYSIAA 185

Human   181 AWALYYLISSFTDQLPWTSCKNSWNTGNCT---NYFSEDNITWTLHSTSPAEEFYTRHVLQIHRS 242
            ...|.|.::|....:||.||.|||||..|:   || ..|:.....|||   .||:...:..  .:
  Fly   186 VVPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENY-DVDDYRVDPHST---VEFFRSMIAS--TA 244

Human   243 KGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKV-----VWVTATFPYIILSVLLVRGATL 302
            ||...: .|||.:.:.::.|:.|:...:.|.|...|||     |.:...|..:.|.:|:....|.
  Fly   245 KGSTSM-SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVTF 308

Human   303 PGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFF-----SLGPGFGVLLAFASYNKFNNNCYQDAL 362
                 ..|.|.   |...|::...|.|.|:...     :||||:|.::..:|||.|.    :||.
  Fly   309 -----DTLHYY---WMPQLDSFDSILATARTALLMAGGALGPGWGSIITLSSYNNFR----RDAE 361

Human   363 VTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVS----EVAKDAGPSLLFITYAEAIANMPAS-TF 422
            ..|:..|:|....|.:.........:...:.|.    .|.:......|::.::........: ..
  Fly   362 RLSIWVCLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFLYLCFSYLFGRFTTTPNL 426

Human   423 FAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLV--TLTFGG 485
            :|.:||.|:....|.:....:..||||:.|||..:  :.|...|::.::.|...|.|  ....|.
  Fly   427 WAFLFFGMIFLSELCALIIQMMSVITALFDEFETL--RSRRILVISSLVFCLTASSVYFCTQLGF 489

Human   486 AYVVKLLEEYATGPAVLTVALIEAVAV---SWFYGITQFCRDVKEMLGFSPGWFWRICWVAI-SP 546
            :.:.:|     ...||.|..||..:.|   :|.||..:|..|::.|||.:...| :|.::.. :|
  Fly   490 SQLTQL-----PNLAVFTHLLISGILVLMTTWVYGRVRFQCDLQFMLGKTISSF-KIFFIRFATP 548

Human   547 LFLLFIICSFLMSPPQLRLFQYNYPY-----WSIILGYCIGTSSFICIPTYIAYRLIITPGTFKE 606
            :||            .|.|||..|.:     ..:::....|......| :|:.|::..|.|.:::
  Fly   549 IFL------------GLCLFQLTYLFTRDRIHDVLIYVSQGLILLTAI-SYMVYKVCRTNGDWRQ 600

Human   607 RIIKSITP 614
            |:.:.:.|
  Fly   601 RLQQCLAP 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		15/58 (26%)
		5HT_transport_N	24..64	CDD:397524	10/45 (22%)
		SLC6sbd_SERT	79..615	CDD:271399	147/574 (26%)
		Interaction with RAB4A	616..624
CG13796	NP_609140.2	SLC5-6-like_sbd	123..610	CDD:444915	138/527 (26%)