Protein Alignment SLC6A4 and CG13794

DIOPT Version :10

• Sequence 1: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_609137.2
• Gene: CG13794 / 34048
• FlyBaseID: FBgn0031936
• Length: 595
• Species: Drosophila melanogaster
• Alignment Length: 579
• Identity: 137/579 - (23%)
• Similarity: 262/579 - (45%)
• Gaps: 62/579 - (10%)

Human    78 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142
            :|..|.|..|::.:..|.|:.| :::...|..:.:.|...:|||.:..:...:|:..:...:||:
  Fly    19 KRGKWDKPTDYIFACFGLALKL-DIFVASYWFFFDMGIFGMLPYLVYMVIYLVPIMVIHSFMGQF 82

Human   143 HRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCK--NSW- 204
            ..:|.||.:| :.|.|||:||....:...:..||:...|..|.::|:||...||| ||:  .||
  Fly    83 SSSGFISAFR-LSPFFKGMGYVSVFLTISMLIYYSIFAAVPLLFMINSFRPTLPW-SCEGFKSWY 145

Human   205 -----NTGNCTNYFSEDNITWTLHSTS--------PAEEFYTRHVLQIHRSKGLQDLG---GISW 253
                 ....|....|||....:.::|.        |:..::.:|...: :.:...||.   .:||
  Fly   146 NESDGKMTTCNMTISEDLTDNSDNNTDFHRPHFHVPSVLYFLKHFESV-QEENYSDLRQDYDLSW 209

Human   254 QLALCIMLIFTVIYFSIWKGVKTS--GKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPN 316
            :.....:|::.::.|..:|..:|:  ||.:........|:|.|...|...||||..|:..|:.|:
  Fly   210 RFVSLFVLVWAMVAFIFYKFSETAMFGKFIRYMVIGTLILLLVCFGRFLFLPGALLGLRKYVTPS 274

Human   317 WQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFT 381
            ..: :..|:. .....:..:.|.|:|.::|.:|:|.|..:....:.:.|        .....|||
  Fly   275 PDE-IAMGIG-STFVMVLHAFGAGWGSVIALSSFNGFKTDIMSYSWIIS--------FGQIFIFT 329

Human   382 VLGYMAEMRNEDVSEVAKDAGPS------LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTF 440
            :.|.::.|.:...:|..:.:...      .|:::.|.|::::.....:..|::.||:...|....
  Fly   330 MFGLVSYMLDHYYNEGIEGSFDKQVLTHWALYLSSATALSSLGWPNLWTFIYYTMLLMAALIVIT 394

Human   441 AGLEGVITAVLDEFPHVWAKRRE-RFVL---AVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAV 501
            ..:..|:.::.|||..:..:::| .|.|   ..|.:.:|.:...:||..|..:..:..::
  Fly   395 TQIFTVLQSLFDEFEVLRVRKQEVTFGLIGGIAVCSFYFCTNHGITFFSALALDAIFSHS----- 454

Human   502 LTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVA-ISPLFLLFIICSFLMSPPQLRL 565
             .:.|:..:.|.|.||..:|.||::.||| .|...|::..:. |:|:.|  |||  |:....:..
  Fly   455 -LLHLLLLLVVLWIYGRERFQRDIEFMLG-QPFASWKVYILRFIAPIIL--IIC--LVVGILVCY 513

Human   566 FQYNYPYWSIILGYCI--GTSSFICIPTYIAYRLIITPGTFKERIIKSITPET--PTEI 620
            .::.|.. :|:||..|  .....:.||.|..|.:..:.|:|.||..::..|..  |.|:
  Fly   514 MEHIYSS-AIVLGMSIILVILPILAIPGYGIYYIYRSTGSFCERFKRTCRPTDWYPVEM 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59
		5HT_transport_N	24..64	CDD:397524
		SLC6sbd_SERT	79..615	CDD:271399	134/569 (24%)
		Interaction with RAB4A	616..624		2/7 (29%)
CG13794	NP_609137.2	SLC5-6-like_sbd	27..509	CDD:271356	118/506 (23%)