Protein Alignment SLC6A4 and NAAT1

DIOPT Version :10

• Sequence 1: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 207/612 - (33%)
• Similarity: 330/612 - (53%)
• Gaps: 66/612 - (10%)

Human    42 QISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFP 106
            |.|||    .|.|:|:...::  |:|....||....||..||..::||:|.|..:|.||||||||
  Fly     7 QPSNG----SSNGSGNGATNA--ASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFP 65

Human   107 YICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGY-----AIC 166
            :..|:|||||||:||.|:....|.|::|:|:.:||:...|.:.|| .:.|.|.|:||     .||
  Fly    66 FTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTIC 129

Human   167 IIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSE---DNI---------- 218
            ||     |||::::|..||||..||..:|||:.|::.|.  ||.|...:   ||:
  Fly   130 II-----SYYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANES 187

Human   219 ------------TWTLHSTSPAEEFYTRHVLQIHRSKGLQD-LGGISWQLALCIMLIFTVIYFSI 270
                        |..|.|:|   |.|..:|: |.....:.| :|...|:|.|.:.:.:.||:..|
  Fly   188 ARNLSGIVANDETEKLQSSS---ELYFLNVV-IKEKLDISDGVGDPDWKLTLALFVAWVVIFLVI 248

Human   271 WKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFF 335
            .:|||:|||..:..|.|||::|.|||:|..||.||..|:||:|:|.|.:||...||.:|..|.||
  Fly   249 MRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFF 313

Human   336 SLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAK 399
            ||..|.|.::.|||||:|::..|:||::.:.::.:||.:.|..||.:||.:| .::.|::.:|.:
  Fly   314 SLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVR 378

Human   400 DAGPSLLFITYAEAIANMPA-STFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP--HVWAKR 461
             :|..|.||:|.:||:...| ...|:::||.||..||:.|..|....::|.:.|:|.  ..|
  Fly   379 -SGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYW--- 439

Human   462 RERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVK 526
              :..|...:..|...||.:|.||.:::.|::.|.....|..:|:.|...:.|.||:..||.|::
  Fly   440 --KVALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIE 502

Human   527 EMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILG---YCIGTSSFIC 588
            .|.......:||:||...:|:.::.|....:::...::..:..:|..:.|.|   :.||.:.|
  Fly   503 FMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQF-- 565

Human   589 IPTYIAYRLIITP-GTFKERIIKSITP 614
             |.:..:.:...| ||:.:.:..|:.|
  Fly   566 -PLWGLWYISRHPQGTYWKSLKASLKP 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		7/16 (44%)
		5HT_transport_N	24..64	CDD:397524	7/21 (33%)
		SLC6sbd_SERT	79..615	CDD:271399	195/575 (34%)
		Interaction with RAB4A	616..624
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	182/510 (36%)