Protein Alignment SLC6A4 and CG10804

DIOPT Version :10

• Sequence 1: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 236/675 - (34%)
• Similarity: 360/675 - (53%)
• Gaps: 86/675 - (12%)

Human     4 TPLNSQKQLSACEDG---EDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPA 65
            |.|:.|....|...|   :...|:..|::..|..|.:..:.:......|:.:..|...
  Fly    49 TSLHHQPLYGATNQGFMSDAFDESSELEQDPPPFGSEASTSKAKAELVAIATASADQQ------- 106

Human    66 TTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGI 130
              ..:..|....|||:|..|:.|||:.|||||.|||||||||:..:|||||||:||.||....||
  Fly   107 --DIVEGEKEGEERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGI 169

Human   131 PLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQL 195
            |:||:|||:||..|.|.|.:|.::.|...|||.:..::::.:|.|||||:||.|.||:.||...|
  Fly   170 PIFYLELAIGQRLRKGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPL 234

Human   196 PWTSCKNSWNTGNCTNYFSEDNITWTLH-----STSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255
            ||..|.        |..:.  |.|:. |     ::||.:.::.|..||...|..:.:  ..::.:
  Fly   235 PWADCP--------TRLYK--NFTYD-HEPECVASSPTQFYWYRTTLQCSESVDMPE--NFNYHM 286

Human   256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKL 320
            |:.:::.:.::|..:.:|:.:|||:|::||.|||::|.:...||.||.||..||.....|.|:.|
  Fly   287 AIALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETL 351

Human   321 LETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGY 385
            |:..||::|..|||||||..||.|:||:|||..|||||:||::.|:.||.||..:|.|:|:|:|:
  Fly   352 LDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGF 416

Human   386 MA--------EMRNEDV--------------SEVAKDA-GPSLLFITYAEAIANMPASTFFAIIF 427
            .|        |.||..|              :|:|..| |..|.||.:.|||...|.:..:|::|
  Fly   417 KATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLF 481

Human   428 FLMLITLGLDSTFAGLEGVITAVLDE--FPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVK 490
            ||||.|||:||.|..||||:|:::|.  ||::   .:|..|.|:..:|...|:......|:|:.:
  Fly   482 FLMLFTLGIDSQFGTLEGVVTSLVDMKLFPNL---PKEYIVGALCFSCCTISMCFANGAGSYIFQ 543

Human   491 LLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICS 555
            |::.:|....:|.:||.|.:::|:.||:.:|..|::.|.|..|.::|..||..:||..::.|:
  Fly   544 LMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTIL-- 606

Human   556 FLMSPPQLRLFQYNY---------------PYWSIILGYCIGTSSFICIPTYIAYRLI------- 598
             |.|..||.....:|               |:|.|::.:.:..||.:.||.....||.
  Fly   607 -LASFYQLLTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLCGIKVVED 670

Human   599 ITPGTFKE---RIIKSITPETPTEI 620
            ..|..|.|   |.:..|.|..|||:
  Fly   671 SDPAWFPEAELREVHGIVPHEPTEL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		11/57 (19%)
		5HT_transport_N	24..64	CDD:397524	5/39 (13%)
		SLC6sbd_SERT	79..615	CDD:271399	219/590 (37%)
		Interaction with RAB4A	616..624		3/5 (60%)
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	210/559 (38%)