Protein Alignment SLC6A4 and CG33296

DIOPT Version :10

• Sequence 1: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 148/578 - (25%)
• Similarity: 262/578 - (45%)
• Gaps: 73/578 - (12%)

Human    78 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142
            :|..|.|..|:|.:..|.|:.| :::...|..:.|.|...:|||.:..:...:|:..:...:||:
  Fly    19 KRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQF 82

Human   143 HRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCK--NSWN 205
            ..:|.|:.:| :.|:|||:||....:.|....||:..:|..|.:||:||...||| ||:  .||:
  Fly    83 SSSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH 145

Human   206 TGN------C--TNYFSEDNITWTLHSTSPAEEFYTRHVLQ--------IHRSKGLQDLGGISWQ 254
            ...      |  |.|...:|  :||...:|: ..|..::.|        ...|:.|..|..:||.
  Fly   146 NRTDEYPTLCHPTIYKQHEN--YTLGVEAPS-RLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWA 207

Human   255 LALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQK 319
            |       ..:|::...:..| .||.:........:::.|..||...|||:.:.:..|:.||.:.
  Fly   208 L-------IAIIFYHFSEPAK-FGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKD 264

Human   320 LLETGVW--IDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTV 382
            ..| |::  ...|.|.|   |.|:|.::|.:|:|.|..:....:.:.|....   |:  :::|.:
  Fly   265 FSE-GIYSTFIMALQAF---GAGWGSVIALSSFNGFKTDIMSYSWIISFGQI---FI--YIMFGL 320

Human   383 LGYMAEMRNEDVSEVA---KDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLE 444
            :.:|.|...:|:|:..   :.....:||::.|.|:..:.....:..|::.||:...|......|.
  Fly   321 VSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLF 385

Human   445 GVITAVLDEFPHVWAKRRE---RFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVAL 506
            .|:.::.|||..:..:::|   ..:..:.|..||   .....|..|...|..:.....::|.:.|
  Fly   386 TVLQSLFDEFEKLKERKQEVTFGIICGLAICSFF---FCTEHGSFYFAILGIDVILAHSLLHLLL 447

Human   507 IEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLL-------FIICSFLMSPPQLR 564
            :  :.|.|.||..:|.||::.||| .|...|::        |:|       |:||..|.....:|
  Fly   448 L--LVVLWIYGQKRFQRDIEFMLG-QPFASWKV--------FILRYTAPIVFLICMILGIIECIR 501

Human   565 LFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPET--PTEI 620
            : .:.:....::||..:....|:.||.|..|.|..:||||.||:.:|..|..  |.|:
  Fly   502 V-HFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTDWYPVEM 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59
		5HT_transport_N	24..64	CDD:397524
		SLC6sbd_SERT	79..615	CDD:271399	145/568 (26%)
		Interaction with RAB4A	616..624		2/7 (29%)
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	126/505 (25%)