DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A3 and GlyT

DIOPT Version :9

Sequence 1:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens
Sequence 2:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	238/589 - (40%)
Similarity:	352/589 - (59%)	Gaps:	31/589 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    38 NGVQLTSSTLTNPRQSPV--EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLV 100
            :|..|.....|.|.....  ...:|.||..:.|||||::|::|.|.||||||||||.|||||||:
  Fly    33 SGTALIQLDATGPGAGGAGESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLI 97

Human   101 PYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPILKGVGFTVILISLYVGFFYNVIIAWAL 164
            |:.:.:||||:||.:|||:.||:...|...|: :.||:.:|:|..:||:|..|..:||:||||.:
  Fly    98 PFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTI 162

Human   165 HYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGL-------NDTFG-----TT------ 211
            .|:|:||...|||.:|..:|::..|......|....::|.       |.|..     ||
  Fly   163 FYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGAL 227

Human   212 ---PAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMP 273
               ||.|||...||.|  |.||::.|..:..|.|||.|...:::..|.|||::|||||:.||..|
  Fly   228 KRPPAEEYFNNFVLGL--SKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFP 290

Human   274 YVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKF 338
            ||||..|.:||||||||..||..||:.|:.:|..|.||.|||.|:.|:|...:|.||..||||||
  Fly   291 YVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKF 355

Human   339 TNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPL 403
            :||||:|:::....|..|||.:|.|:||.:|::|.:.:|.:..|...|.||.||:|||.:..||:
  Fly   356 SNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPV 420

Human   404 SSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGG 468
            |..|||:||:||||||:||....||:|.|.::|.|..|.:::....|.:.:..::..|...||.|
  Fly   421 SPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSG 485

Human   469 IYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRP---SLYWRLCWKLVSPC 530
            :|...|:|.:||..|:|...:.|.|.:||.||..:|.:|||.|.|:|.   :.:|.:.|:.::|.
  Fly   486 MYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPA 550

Human   531 FLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG--SFREKLAY 593
            .|||::..:.|.::|..||.|::|.||:|:||::....:.::.:.|..:....|.  |||:::.:
  Fly   551 TLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKH 615

Human   594 AIAP 597
            .:.|
  Fly   616 LLQP 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	234/565 (41%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		7/30 (23%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	229/547 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820