Protein Alignment SLC6A3 and CG8850

DIOPT Version :9

• Sequence 1: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 195/568 - (34%)
• Similarity: 305/568 - (53%)
• Gaps: 14/568 - (2%)

Human    33 LVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGA 97
            ::....|.:||    .|.......:..|:.|.:.::||.|.|..:|.|.||||||::..:|||||
  Fly    34 VIYSAEGEELT----INCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGA 94

Human    98 FLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAW 162
            ||:||::.:::.|.|::|:|:.:|||:..|....:.:.||::|:.:..:..:.....:|..|:|.
  Fly    95 FLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMAL 159

Human   163 ALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQS 227
            .:.||.:||:..|||.:|...|.. :|. |....::.|||.:.   |.:.|..:|.:.||...:|
  Fly   160 TIRYLVASFSEVLPWTYCLVEWGK-SCV-ATGATAANDSSIVQ---GVSSAELFFTQTVLREPES 219

Human   228 HGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAID 292
            ...:.||.|.|.|..||:...|::...|.||:::|||..:..|..|||::..||:|.||||||..
  Fly   220 LDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQ 284

Human   293 GIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTS 357
            ||..:|...:.:|....||..|.||:.|||.:.||.|:.::|:|.|..|.::|.|:.|:|:||||
  Fly   285 GIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTS 349

Human   358 FSSGFVVFSFLGYMA-QKHSVPIGDVAKDGPGLIFIIYPEAIATLP-LSSAWAVVFFIMLLTLGI 420
            ..:|.::|..||.:| :.::..|..|.|.|.||.||.||||||... |...:||:||.|||.|||
  Fly   350 ILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGI 414

Human   421 DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSIL 485
            .|.:|...:|:..:.|.|  .|....|..:...:..||..|..:|.||.:|..|:|.:......|
  Fly   415 GSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIAL 477

Human   486 FGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGA 550
            ...:.|.:.|.|.|||.:...||:.|...:.|.|||:||.:|:|..:..|:|..:.::.|..|..
  Fly   478 VLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYRG 542

Human   551 YIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG-SFREKLAYAIAP 597
            ..:|......||:|....:..:|.:|.......|| :|..|...|:.|
  Fly   543 VQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	191/541 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		8/29 (28%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	176/480 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820