Protein Alignment SLC6A3 and CG15279

DIOPT Version :10

• Sequence 1: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 210/594 - (35%)
• Similarity: 327/594 - (55%)
• Gaps: 49/594 - (8%)

Human    43 TSSTLTNPRQSPV--------EA----QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGG 95
            |:||:.....||.        ||    ::|.||||.::||:|.|..:|.|.||||||:....|||
  Fly    21 TASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGG 85

Human    96 GAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVG----FTVILISLYVGFFY 156
            ||||:|||:.:.:.|.|::|:|:.:|||:..|:..|:.:||.:||||    |.|.::|.|    |
  Fly    86 GAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTY----Y 146

Human   157 NVIIAWALHYLFSSFTTELPW--------IHCNNS------WNSPNCSDAHPGDSSGDSSGLNDT 207
            ..::|....|...||...|||        |||.||      |:....:|..|.:.:..|.  ||.
  Fly   147 AALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASNWSQLESNDQRPQNYTMKSQ--NDR 209

Human   208 FGTTPAAEYFERGVLHLHQSHGIDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITAT 271
            . .|.:..||.:.|  ||:...|:: :|.|.|:|...|.:....::|.:.:|||:|||..:..|.
  Fly   210 V-ITSSEWYFVKEV--LHEKPNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLAL 271

Human   272 MPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYN 336
            .|||::..||:|.|||||:||||..::...:.::.:..||..|.||..:||.|.||.:|.:||:|
  Fly   272 FPYVIMGVLLVRAVTLPGSIDGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFN 336

Human   337 KFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV---PIGDVAKDGPGLIFIIYPEAI 398
            ||.:|.:|||.:.|.::::||..:||.:|..||::|  |.:   .||.|.|.|.||.||.||:||
  Fly   337 KFGHNVHRDAAIVTGLDTMTSLLAGFTIFGILGHLA--HEIGTDDIGSVVKGGAGLAFISYPDAI 399

Human   399 ATLP-LSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLF 462
            |... |...::|:||:||..|||.|.:......:|.:.|.|....:.:  .:|.|.:.:|.:.|.
  Fly   400 AKFKNLPQIFSVLFFLMLFVLGIGSNIAMTSCSVTAIRDRFPNFGQWQ--CSLLIAVVSFFIGLM 462

Human   463 CVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLV 527
            .:|.||.|:.||:|.|.|....|...:.|...:.|.||..:...||:.|.|::..|||||||.::
  Fly   463 YITPGGQYMLTLVDFFGASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSII 527

Human   528 SPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG-SFREKL 591
            :|..:..:::....|::|..|...::|:|:.::||:|....:..:||:........|| :...|:
  Fly   528 TPLIMTVILIYFYATYQPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKI 592

Human   592 AYAIAPEKD 600
            ..|..|:|:
  Fly   593 RGAFTPKKN 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	203/565 (36%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		7/29 (24%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	201/560 (36%)