DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC6A3 and ine

DIOPT Version :9

Sequence 1:NP_001035.1 Gene:SLC6A3 / 6531 HGNCID:11049 Length:620 Species:Homo sapiens
Sequence 2:NP_001162871.1 Gene:ine / 33659 FlyBaseID:FBgn0011603 Length:943 Species:Drosophila melanogaster


Alignment Length:621 Identity:240/621 - (38%)
Similarity:371/621 - (59%) Gaps:46/621 - (7%)


- Green bases have known domain annotations that are detailed below.


Human     3 KSKCSVGLMSS---------VVAPAKE---------PNAVGPKEVELILVKEQNGVQLTSSTLTN 49
            :|..|:|:.|:         |...|.|         |..:|..:.:..|.......||      .
  Fly   276 RSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQL------K 334

Human    50 PRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLF 114
            |||        :.|..|:.|:|:.||::|.|.|||||||:|||:|||.|||||.:.:.|..:||.
  Fly   335 PRQ--------QHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLL 391

Human   115 YMELALGQFNREGAAG-VWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWI 178
            :|||::||:...|..| :.::||:.||.|...:::|..:..:|:|||.::::|.|:||.||:|||
  Fly   392 FMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWI 456

Human   179 HCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTAC 243
            .|||.||:|:|   ......|.::...|| ..||:.|:||..||.:  |.|::..|..||:|.||
  Fly   457 DCNNRWNTPDC---WVPQRKGINASAPDT-SRTPSEEFFENKVLQI--SGGLEYPGMMRWELFAC 515

Human   244 LVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEA 308
            |:...:::||:.||.:|:|.||.:.|||.|:|::..|::|.|||.||.:|:|.:....:..|..|
  Fly   516 LICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNA 580

Human   309 SVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQ 373
            :|||:||:|...|||:.||.:|:|:||||:.||..||.:..:::|.:||...|...||.||.:|.
  Fly   581 NVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLAL 645

Human   374 KHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF 438
            :.:..:.||..||||:||::||:|:|.:|.:..|||:||.|||.||::|....:|.|:|.:.|.|
  Fly   646 EQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGF 710

Human   439 -QLLHRH---RELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFY 499
             :.:.||   .|:..||:.:.:.|..:..:..||||.|.|:||:||..:|:|....:.|.:||||
  Fly   711 PRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFY 775

Human   500 GVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPP--HYGAYIFPDWANALGW 562
            |.|:.|.:::||||:.||.|.|.||.::.||.|..:.|:|::.:..|  |.|.|.:||||..:||
  Fly   776 GTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGW 840

Human   563 VIATSSMAMVPIYAAYKFCSLPG-SFREKLAYAIAP 597
            :.|:.|:..:|.||...|....| :|.|::...:.|
  Fly   841 MFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC6A3NP_001035.1 SLC6sbd_DAT1 60..614 CDD:212083 225/546 (41%)
Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201 561..590 10/29 (34%)
ineNP_001162871.1 SLC5-6-like_sbd 337..876 CDD:294310 225/552 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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